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Progressive Volume Loss and White Matter Degeneration in Cstb-Deficient Mice: A Diffusion Tensor and Longitudinal Volumetry MRI Study
Unverricht-Lundborg type progressive myoclonus epilepsy (EPM1, OMIM 254800) is an autosomal recessive disorder characterized by onset at the age of 6 to 16 years, incapacitating stimulus-sensitive myoclonus and tonic-clonic epileptic seizures. It is caused by mutations in the gene encoding cystatin...
Autores principales: | Manninen, Otto, Laitinen, Teemu, Lehtimäki, Kimmo K., Tegelberg, Saara, Lehesjoki, Anna-Elina, Gröhn, Olli, Kopra, Outi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948351/ https://www.ncbi.nlm.nih.gov/pubmed/24603771 http://dx.doi.org/10.1371/journal.pone.0090709 |
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