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Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention
Japan has become an aging society, resulting in an increased prevalence of coronary artery disease. However, clinical outcomes of elderly Japanese patients after percutaneous coronary intervention (PCI) remain unclear. Of the 15,227 patients in the Shinken Database, a single-hospital-based cohort of...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948512/ https://www.ncbi.nlm.nih.gov/pubmed/23552901 http://dx.doi.org/10.1007/s00380-013-0339-9 |
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author | Kaneko, Hidehiro Yajima, Junji Oikawa, Yuji Tanaka, Shingo Fukamachi, Daisuke Suzuki, Shinya Sagara, Koichi Otsuka, Takayuki Matsuno, Shunsuke Funada, Ryuichi Kano, Hiroto Uejima, Tokuhisa Koike, Akira Nagashima, Kazuyuki Kirigaya, Hajime Sawada, Hitoshi Aizawa, Tadanori Yamashita, Takeshi |
author_facet | Kaneko, Hidehiro Yajima, Junji Oikawa, Yuji Tanaka, Shingo Fukamachi, Daisuke Suzuki, Shinya Sagara, Koichi Otsuka, Takayuki Matsuno, Shunsuke Funada, Ryuichi Kano, Hiroto Uejima, Tokuhisa Koike, Akira Nagashima, Kazuyuki Kirigaya, Hajime Sawada, Hitoshi Aizawa, Tadanori Yamashita, Takeshi |
author_sort | Kaneko, Hidehiro |
collection | PubMed |
description | Japan has become an aging society, resulting in an increased prevalence of coronary artery disease. However, clinical outcomes of elderly Japanese patients after percutaneous coronary intervention (PCI) remain unclear. Of the 15,227 patients in the Shinken Database, a single-hospital-based cohort of new patients, 1,214 patients who underwent PCI, was evaluated to determine the differences in clinical outcomes between the elderly (≥75 years) (n = 260) and the non-elderly (<75 years) (n = 954) patients. A major adverse cardiac event (MACE) was defined as a composite end point, including all-cause death, myocardial infarction (MI), and target lesion revascularization. Male gender and obesity were less common, and the estimated glomerular filtration rate (eGFR) was significantly lower in the elderly than in the non-elderly. Left ventricular ejection fraction (LVEF) was comparable between these groups. Left main trunk disease and multivessel disease were more common in the elderly than in the non-elderly group. Occurrence of MACE was frequent, and the incidences of all-cause death, cardiac death, and the admission rate for heart failure were significantly higher in the elderly patients. Multivariate analysis showed that prior MI, low eGFR, and poor LVEF were independent predictors for all-cause death in the elderly patients. Elderly patients had worse clinical outcomes than the non-elderly patients. Low eGFR and LVEF were independent predictors of all-cause death after PCI, suggesting that left ventricular dysfunction and renal dysfunction might synergistically contribute to the adverse clinical outcomes of the elderly patients undergoing PCI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00380-013-0339-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3948512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-39485122014-03-14 Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention Kaneko, Hidehiro Yajima, Junji Oikawa, Yuji Tanaka, Shingo Fukamachi, Daisuke Suzuki, Shinya Sagara, Koichi Otsuka, Takayuki Matsuno, Shunsuke Funada, Ryuichi Kano, Hiroto Uejima, Tokuhisa Koike, Akira Nagashima, Kazuyuki Kirigaya, Hajime Sawada, Hitoshi Aizawa, Tadanori Yamashita, Takeshi Heart Vessels Original Article Japan has become an aging society, resulting in an increased prevalence of coronary artery disease. However, clinical outcomes of elderly Japanese patients after percutaneous coronary intervention (PCI) remain unclear. Of the 15,227 patients in the Shinken Database, a single-hospital-based cohort of new patients, 1,214 patients who underwent PCI, was evaluated to determine the differences in clinical outcomes between the elderly (≥75 years) (n = 260) and the non-elderly (<75 years) (n = 954) patients. A major adverse cardiac event (MACE) was defined as a composite end point, including all-cause death, myocardial infarction (MI), and target lesion revascularization. Male gender and obesity were less common, and the estimated glomerular filtration rate (eGFR) was significantly lower in the elderly than in the non-elderly. Left ventricular ejection fraction (LVEF) was comparable between these groups. Left main trunk disease and multivessel disease were more common in the elderly than in the non-elderly group. Occurrence of MACE was frequent, and the incidences of all-cause death, cardiac death, and the admission rate for heart failure were significantly higher in the elderly patients. Multivariate analysis showed that prior MI, low eGFR, and poor LVEF were independent predictors for all-cause death in the elderly patients. Elderly patients had worse clinical outcomes than the non-elderly patients. Low eGFR and LVEF were independent predictors of all-cause death after PCI, suggesting that left ventricular dysfunction and renal dysfunction might synergistically contribute to the adverse clinical outcomes of the elderly patients undergoing PCI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00380-013-0339-9) contains supplementary material, which is available to authorized users. Springer Japan 2013-04-04 2014 /pmc/articles/PMC3948512/ /pubmed/23552901 http://dx.doi.org/10.1007/s00380-013-0339-9 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Kaneko, Hidehiro Yajima, Junji Oikawa, Yuji Tanaka, Shingo Fukamachi, Daisuke Suzuki, Shinya Sagara, Koichi Otsuka, Takayuki Matsuno, Shunsuke Funada, Ryuichi Kano, Hiroto Uejima, Tokuhisa Koike, Akira Nagashima, Kazuyuki Kirigaya, Hajime Sawada, Hitoshi Aizawa, Tadanori Yamashita, Takeshi Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention |
title | Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention |
title_full | Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention |
title_fullStr | Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention |
title_full_unstemmed | Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention |
title_short | Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention |
title_sort | impact of aging on the clinical outcomes of japanese patients with coronary artery disease after percutaneous coronary intervention |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948512/ https://www.ncbi.nlm.nih.gov/pubmed/23552901 http://dx.doi.org/10.1007/s00380-013-0339-9 |
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