Cargando…

Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention

Japan has become an aging society, resulting in an increased prevalence of coronary artery disease. However, clinical outcomes of elderly Japanese patients after percutaneous coronary intervention (PCI) remain unclear. Of the 15,227 patients in the Shinken Database, a single-hospital-based cohort of...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaneko, Hidehiro, Yajima, Junji, Oikawa, Yuji, Tanaka, Shingo, Fukamachi, Daisuke, Suzuki, Shinya, Sagara, Koichi, Otsuka, Takayuki, Matsuno, Shunsuke, Funada, Ryuichi, Kano, Hiroto, Uejima, Tokuhisa, Koike, Akira, Nagashima, Kazuyuki, Kirigaya, Hajime, Sawada, Hitoshi, Aizawa, Tadanori, Yamashita, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948512/
https://www.ncbi.nlm.nih.gov/pubmed/23552901
http://dx.doi.org/10.1007/s00380-013-0339-9
_version_ 1782306786217295872
author Kaneko, Hidehiro
Yajima, Junji
Oikawa, Yuji
Tanaka, Shingo
Fukamachi, Daisuke
Suzuki, Shinya
Sagara, Koichi
Otsuka, Takayuki
Matsuno, Shunsuke
Funada, Ryuichi
Kano, Hiroto
Uejima, Tokuhisa
Koike, Akira
Nagashima, Kazuyuki
Kirigaya, Hajime
Sawada, Hitoshi
Aizawa, Tadanori
Yamashita, Takeshi
author_facet Kaneko, Hidehiro
Yajima, Junji
Oikawa, Yuji
Tanaka, Shingo
Fukamachi, Daisuke
Suzuki, Shinya
Sagara, Koichi
Otsuka, Takayuki
Matsuno, Shunsuke
Funada, Ryuichi
Kano, Hiroto
Uejima, Tokuhisa
Koike, Akira
Nagashima, Kazuyuki
Kirigaya, Hajime
Sawada, Hitoshi
Aizawa, Tadanori
Yamashita, Takeshi
author_sort Kaneko, Hidehiro
collection PubMed
description Japan has become an aging society, resulting in an increased prevalence of coronary artery disease. However, clinical outcomes of elderly Japanese patients after percutaneous coronary intervention (PCI) remain unclear. Of the 15,227 patients in the Shinken Database, a single-hospital-based cohort of new patients, 1,214 patients who underwent PCI, was evaluated to determine the differences in clinical outcomes between the elderly (≥75 years) (n = 260) and the non-elderly (<75 years) (n = 954) patients. A major adverse cardiac event (MACE) was defined as a composite end point, including all-cause death, myocardial infarction (MI), and target lesion revascularization. Male gender and obesity were less common, and the estimated glomerular filtration rate (eGFR) was significantly lower in the elderly than in the non-elderly. Left ventricular ejection fraction (LVEF) was comparable between these groups. Left main trunk disease and multivessel disease were more common in the elderly than in the non-elderly group. Occurrence of MACE was frequent, and the incidences of all-cause death, cardiac death, and the admission rate for heart failure were significantly higher in the elderly patients. Multivariate analysis showed that prior MI, low eGFR, and poor LVEF were independent predictors for all-cause death in the elderly patients. Elderly patients had worse clinical outcomes than the non-elderly patients. Low eGFR and LVEF were independent predictors of all-cause death after PCI, suggesting that left ventricular dysfunction and renal dysfunction might synergistically contribute to the adverse clinical outcomes of the elderly patients undergoing PCI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00380-013-0339-9) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-3948512
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer Japan
record_format MEDLINE/PubMed
spelling pubmed-39485122014-03-14 Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention Kaneko, Hidehiro Yajima, Junji Oikawa, Yuji Tanaka, Shingo Fukamachi, Daisuke Suzuki, Shinya Sagara, Koichi Otsuka, Takayuki Matsuno, Shunsuke Funada, Ryuichi Kano, Hiroto Uejima, Tokuhisa Koike, Akira Nagashima, Kazuyuki Kirigaya, Hajime Sawada, Hitoshi Aizawa, Tadanori Yamashita, Takeshi Heart Vessels Original Article Japan has become an aging society, resulting in an increased prevalence of coronary artery disease. However, clinical outcomes of elderly Japanese patients after percutaneous coronary intervention (PCI) remain unclear. Of the 15,227 patients in the Shinken Database, a single-hospital-based cohort of new patients, 1,214 patients who underwent PCI, was evaluated to determine the differences in clinical outcomes between the elderly (≥75 years) (n = 260) and the non-elderly (<75 years) (n = 954) patients. A major adverse cardiac event (MACE) was defined as a composite end point, including all-cause death, myocardial infarction (MI), and target lesion revascularization. Male gender and obesity were less common, and the estimated glomerular filtration rate (eGFR) was significantly lower in the elderly than in the non-elderly. Left ventricular ejection fraction (LVEF) was comparable between these groups. Left main trunk disease and multivessel disease were more common in the elderly than in the non-elderly group. Occurrence of MACE was frequent, and the incidences of all-cause death, cardiac death, and the admission rate for heart failure were significantly higher in the elderly patients. Multivariate analysis showed that prior MI, low eGFR, and poor LVEF were independent predictors for all-cause death in the elderly patients. Elderly patients had worse clinical outcomes than the non-elderly patients. Low eGFR and LVEF were independent predictors of all-cause death after PCI, suggesting that left ventricular dysfunction and renal dysfunction might synergistically contribute to the adverse clinical outcomes of the elderly patients undergoing PCI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00380-013-0339-9) contains supplementary material, which is available to authorized users. Springer Japan 2013-04-04 2014 /pmc/articles/PMC3948512/ /pubmed/23552901 http://dx.doi.org/10.1007/s00380-013-0339-9 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Kaneko, Hidehiro
Yajima, Junji
Oikawa, Yuji
Tanaka, Shingo
Fukamachi, Daisuke
Suzuki, Shinya
Sagara, Koichi
Otsuka, Takayuki
Matsuno, Shunsuke
Funada, Ryuichi
Kano, Hiroto
Uejima, Tokuhisa
Koike, Akira
Nagashima, Kazuyuki
Kirigaya, Hajime
Sawada, Hitoshi
Aizawa, Tadanori
Yamashita, Takeshi
Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention
title Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention
title_full Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention
title_fullStr Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention
title_full_unstemmed Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention
title_short Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention
title_sort impact of aging on the clinical outcomes of japanese patients with coronary artery disease after percutaneous coronary intervention
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948512/
https://www.ncbi.nlm.nih.gov/pubmed/23552901
http://dx.doi.org/10.1007/s00380-013-0339-9
work_keys_str_mv AT kanekohidehiro impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT yajimajunji impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT oikawayuji impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT tanakashingo impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT fukamachidaisuke impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT suzukishinya impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT sagarakoichi impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT otsukatakayuki impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT matsunoshunsuke impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT funadaryuichi impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT kanohiroto impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT uejimatokuhisa impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT koikeakira impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT nagashimakazuyuki impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT kirigayahajime impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT sawadahitoshi impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT aizawatadanori impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention
AT yamashitatakeshi impactofagingontheclinicaloutcomesofjapanesepatientswithcoronaryarterydiseaseafterpercutaneouscoronaryintervention