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The cross-sectional association of sitting time with carotid artery stiffness in young adults

OBJECTIVES: Physical activity is negatively associated with arterial stiffness. However, the relationship between sedentary behaviour and arterial stiffness is poorly understood. In this study, we aimed to investigate the association of sedentary behaviour with arterial stiffness among young adults....

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Autores principales: Huynh, Quan L, Blizzard, Christopher L, Sharman, James E, Magnussen, Costan G, Dwyer, Terence, Venn, Alison J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948580/
https://www.ncbi.nlm.nih.gov/pubmed/24604484
http://dx.doi.org/10.1136/bmjopen-2013-004384
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author Huynh, Quan L
Blizzard, Christopher L
Sharman, James E
Magnussen, Costan G
Dwyer, Terence
Venn, Alison J
author_facet Huynh, Quan L
Blizzard, Christopher L
Sharman, James E
Magnussen, Costan G
Dwyer, Terence
Venn, Alison J
author_sort Huynh, Quan L
collection PubMed
description OBJECTIVES: Physical activity is negatively associated with arterial stiffness. However, the relationship between sedentary behaviour and arterial stiffness is poorly understood. In this study, we aimed to investigate the association of sedentary behaviour with arterial stiffness among young adults. DESIGN: Cross-sectional. SETTING: 34 study clinics across Australia during 2004–2006. PARTICIPANTS: 2328 participants (49.4% male) aged 26–36 years who were followed up from a nationally representative sample of Australian schoolchildren in 1985. MEASUREMENTS: Arterial stiffness was measured by carotid ultrasound. Sitting time per weekday and weekend day, and physical activity were self-reported by questionnaire. Cardiorespiratory fitness was estimated as physical work capacity at a heart rate of 170 bpm. Anthropometry, blood pressure, resting heart rate and blood biochemistry were measured. Potential confounders, including strength training, education, smoking, diet, alcohol consumption and parity, were self-reported. Rank correlation was used for analysis. RESULTS: Sitting time per weekend day, but not per weekday, was correlated with arterial stiffness (males r=0.11 p<0.01, females r=0.08, p<0.05) and cardiorespiratory fitness (males r = −0.14, females r = −0.08, p<0.05), and also with fatness and resting heart rate. One additional hour of sitting per weekend day was associated with 5.6% (males p=0.046) and 8.6% (females p=0.05) higher risk of having metabolic syndrome. These associations were independent of physical activity and other potential confounders. The association of sitting time per weekend day with arterial stiffness was not mediated by resting heart rate, fatness or metabolic syndrome. CONCLUSIONS: Our study demonstrates a positive association of sitting time with arterial stiffness. The greater role of sitting time per weekend day in prediction of arterial stiffness and cardiometabolic risk than that of sitting time per weekday may be due to better reflection of discretionary sitting behaviour.
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spelling pubmed-39485802014-03-12 The cross-sectional association of sitting time with carotid artery stiffness in young adults Huynh, Quan L Blizzard, Christopher L Sharman, James E Magnussen, Costan G Dwyer, Terence Venn, Alison J BMJ Open Epidemiology OBJECTIVES: Physical activity is negatively associated with arterial stiffness. However, the relationship between sedentary behaviour and arterial stiffness is poorly understood. In this study, we aimed to investigate the association of sedentary behaviour with arterial stiffness among young adults. DESIGN: Cross-sectional. SETTING: 34 study clinics across Australia during 2004–2006. PARTICIPANTS: 2328 participants (49.4% male) aged 26–36 years who were followed up from a nationally representative sample of Australian schoolchildren in 1985. MEASUREMENTS: Arterial stiffness was measured by carotid ultrasound. Sitting time per weekday and weekend day, and physical activity were self-reported by questionnaire. Cardiorespiratory fitness was estimated as physical work capacity at a heart rate of 170 bpm. Anthropometry, blood pressure, resting heart rate and blood biochemistry were measured. Potential confounders, including strength training, education, smoking, diet, alcohol consumption and parity, were self-reported. Rank correlation was used for analysis. RESULTS: Sitting time per weekend day, but not per weekday, was correlated with arterial stiffness (males r=0.11 p<0.01, females r=0.08, p<0.05) and cardiorespiratory fitness (males r = −0.14, females r = −0.08, p<0.05), and also with fatness and resting heart rate. One additional hour of sitting per weekend day was associated with 5.6% (males p=0.046) and 8.6% (females p=0.05) higher risk of having metabolic syndrome. These associations were independent of physical activity and other potential confounders. The association of sitting time per weekend day with arterial stiffness was not mediated by resting heart rate, fatness or metabolic syndrome. CONCLUSIONS: Our study demonstrates a positive association of sitting time with arterial stiffness. The greater role of sitting time per weekend day in prediction of arterial stiffness and cardiometabolic risk than that of sitting time per weekday may be due to better reflection of discretionary sitting behaviour. BMJ Publishing Group 2014-03-06 /pmc/articles/PMC3948580/ /pubmed/24604484 http://dx.doi.org/10.1136/bmjopen-2013-004384 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Epidemiology
Huynh, Quan L
Blizzard, Christopher L
Sharman, James E
Magnussen, Costan G
Dwyer, Terence
Venn, Alison J
The cross-sectional association of sitting time with carotid artery stiffness in young adults
title The cross-sectional association of sitting time with carotid artery stiffness in young adults
title_full The cross-sectional association of sitting time with carotid artery stiffness in young adults
title_fullStr The cross-sectional association of sitting time with carotid artery stiffness in young adults
title_full_unstemmed The cross-sectional association of sitting time with carotid artery stiffness in young adults
title_short The cross-sectional association of sitting time with carotid artery stiffness in young adults
title_sort cross-sectional association of sitting time with carotid artery stiffness in young adults
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948580/
https://www.ncbi.nlm.nih.gov/pubmed/24604484
http://dx.doi.org/10.1136/bmjopen-2013-004384
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