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Reticulocyte maturity indices in iron deficiency anemia
OBJECTIVE: The aim of this study was to analyze the reticulocyte maturity indices (low, medium, and high fluorescence ratios) in iron deficient 1- to 6-year-old children, and identify the prevalence of iron deficiency anemia in this population. METHODS: The present study included 39 subjects, divide...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Hematologia e Hemoterapia
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948662/ https://www.ncbi.nlm.nih.gov/pubmed/24624032 http://dx.doi.org/10.5581/1516-8484.20140009 |
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author | Wollmann, Muriel Gerzson, Branca Maria Cerezer Schwert, Vanessa Figuera, Rafael Weber de Oliveira Ritzel, Guilherme |
author_facet | Wollmann, Muriel Gerzson, Branca Maria Cerezer Schwert, Vanessa Figuera, Rafael Weber de Oliveira Ritzel, Guilherme |
author_sort | Wollmann, Muriel |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to analyze the reticulocyte maturity indices (low, medium, and high fluorescence ratios) in iron deficient 1- to 6-year-old children, and identify the prevalence of iron deficiency anemia in this population. METHODS: The present study included 39 subjects, divided into two groups: control subjects (n = 33), and subjects with iron deficiency anemia (n = 6). The results were analyzed by Student’s t-test for comparison of means. Differences were considered significant when two-tailed p-value < 0.05. RESULTS: Subjects with iron deficiency anemia presented increases in the proportion of mean (10.3 ± 4.7% us. 6.0 ± 3.4%; p-value = 0.003), and high fluorescence reticulocytes (2.3 ± 0.87% vs. 0.9 ± 0.9%; p-value = 0.03) compared to the control group. The prevalence of anemia in this population was 15% (n = 6). CONCLUSION: The indices related to immaturity of reticulocytes are higher in the presence of iron deficiency, thus demonstrating a deficiency in the raw material to form hemoglobin and are, therefore, possible early markers of iron deficiency and anemia. We emphasize the need to standardize these indices for use in clinical practice and lab test results. © 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. |
format | Online Article Text |
id | pubmed-3948662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-39486622014-03-12 Reticulocyte maturity indices in iron deficiency anemia Wollmann, Muriel Gerzson, Branca Maria Cerezer Schwert, Vanessa Figuera, Rafael Weber de Oliveira Ritzel, Guilherme Rev Bras Hematol Hemoter Original article OBJECTIVE: The aim of this study was to analyze the reticulocyte maturity indices (low, medium, and high fluorescence ratios) in iron deficient 1- to 6-year-old children, and identify the prevalence of iron deficiency anemia in this population. METHODS: The present study included 39 subjects, divided into two groups: control subjects (n = 33), and subjects with iron deficiency anemia (n = 6). The results were analyzed by Student’s t-test for comparison of means. Differences were considered significant when two-tailed p-value < 0.05. RESULTS: Subjects with iron deficiency anemia presented increases in the proportion of mean (10.3 ± 4.7% us. 6.0 ± 3.4%; p-value = 0.003), and high fluorescence reticulocytes (2.3 ± 0.87% vs. 0.9 ± 0.9%; p-value = 0.03) compared to the control group. The prevalence of anemia in this population was 15% (n = 6). CONCLUSION: The indices related to immaturity of reticulocytes are higher in the presence of iron deficiency, thus demonstrating a deficiency in the raw material to form hemoglobin and are, therefore, possible early markers of iron deficiency and anemia. We emphasize the need to standardize these indices for use in clinical practice and lab test results. © 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. Sociedade Brasileira de Hematologia e Hemoterapia 2014 2014-04-23 /pmc/articles/PMC3948662/ /pubmed/24624032 http://dx.doi.org/10.5581/1516-8484.20140009 Text en © 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Original article Wollmann, Muriel Gerzson, Branca Maria Cerezer Schwert, Vanessa Figuera, Rafael Weber de Oliveira Ritzel, Guilherme Reticulocyte maturity indices in iron deficiency anemia |
title | Reticulocyte maturity indices in iron deficiency anemia |
title_full | Reticulocyte maturity indices in iron deficiency anemia |
title_fullStr | Reticulocyte maturity indices in iron deficiency anemia |
title_full_unstemmed | Reticulocyte maturity indices in iron deficiency anemia |
title_short | Reticulocyte maturity indices in iron deficiency anemia |
title_sort | reticulocyte maturity indices in iron deficiency anemia |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948662/ https://www.ncbi.nlm.nih.gov/pubmed/24624032 http://dx.doi.org/10.5581/1516-8484.20140009 |
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