Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease

Dyskinesia is a major side effect of an otherwise effective L-DOPA treatment in Parkinson's patients. The prevailing view for the underlying presynaptic mechanism of L-DOPA-induced dyskinesia (LID) suggests that surges in dopamine (DA) via uncontrolled release from serotonergic terminals result...

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Detalles Bibliográficos
Autores principales: Sahin, Gurdal, Thompson, Lachlan H., Lavisse, Sonia, Ozgur, Merve, Rbah-Vidal, Latifa, Dollé, Frédéric, Hantraye, Philippe, Kirik, Deniz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948692/
https://www.ncbi.nlm.nih.gov/pubmed/24614598
http://dx.doi.org/10.1371/journal.pone.0090759

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