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The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria

BACKGROUND: The Kidney Disease: Improving Global Outcomes chronic kidney disease (CKD) guidelines recommend that CKD be classified based on the etiology, glomerular filtration rate (GFR) and degree of albuminuria. The present study aimed to establish a method that predicts the presence of microalbum...

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Autores principales: Yamamoto, Kyoko, Yamamoto, Hiroyuki, Yoshida, Katsumi, Niwa, Koichiro, Nishi, Yutaro, Mizuno, Atsushi, Kuwabara, Masanari, Asano, Taku, Sakoda, Kunihiro, Niinuma, Hiroyuki, Nakahara, Fumiko, Takeda, Kyoko, Shindoh, Chiyohiko, Komatsu, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948741/
https://www.ncbi.nlm.nih.gov/pubmed/24614247
http://dx.doi.org/10.1371/journal.pone.0091067
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author Yamamoto, Kyoko
Yamamoto, Hiroyuki
Yoshida, Katsumi
Niwa, Koichiro
Nishi, Yutaro
Mizuno, Atsushi
Kuwabara, Masanari
Asano, Taku
Sakoda, Kunihiro
Niinuma, Hiroyuki
Nakahara, Fumiko
Takeda, Kyoko
Shindoh, Chiyohiko
Komatsu, Yasuhiro
author_facet Yamamoto, Kyoko
Yamamoto, Hiroyuki
Yoshida, Katsumi
Niwa, Koichiro
Nishi, Yutaro
Mizuno, Atsushi
Kuwabara, Masanari
Asano, Taku
Sakoda, Kunihiro
Niinuma, Hiroyuki
Nakahara, Fumiko
Takeda, Kyoko
Shindoh, Chiyohiko
Komatsu, Yasuhiro
author_sort Yamamoto, Kyoko
collection PubMed
description BACKGROUND: The Kidney Disease: Improving Global Outcomes chronic kidney disease (CKD) guidelines recommend that CKD be classified based on the etiology, glomerular filtration rate (GFR) and degree of albuminuria. The present study aimed to establish a method that predicts the presence of microalbuminuria by measuring the total urine protein-to-creatinine ratio (TPCR) in patients with cardiovascular disease (CVD) risk factors. METHODS AND RESULTS: We obtained urine samples from 1,033 patients who visited the cardiovascular clinic at St. Luke's International Hospital from February 2012 to August 2012. We measured the TPCR and the urine albumin-to-creatinine ratio (ACR) from random spot urine samples. We performed correlation, receiver operating characteristic (ROC) curve, sensitivity, and subgroup analyses. There was a strong positive correlation between the TPCR and ACR (R(2) = 0.861, p<0.001). A ROC curve analysis for the TPCR revealed a sensitivity of 94.4%, a specificity of 86.1%, and an area under the curve of 0.903 for detecting microalbuminuria for a TPCR cut-off value of 84 mg/g of creatinine. The subgroup analysis indicated that the cut-off value could be used for patients with CVD risk factors. CONCLUSIONS: These results suggest that the TPCR with an appropriate cut-off value could be used to screen for the presence of microalbuminuria in patients with CVD risk factors. This simple, inexpensive measurement has broader applications, leading to earlier intervention and public benefit.
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spelling pubmed-39487412014-03-13 The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria Yamamoto, Kyoko Yamamoto, Hiroyuki Yoshida, Katsumi Niwa, Koichiro Nishi, Yutaro Mizuno, Atsushi Kuwabara, Masanari Asano, Taku Sakoda, Kunihiro Niinuma, Hiroyuki Nakahara, Fumiko Takeda, Kyoko Shindoh, Chiyohiko Komatsu, Yasuhiro PLoS One Research Article BACKGROUND: The Kidney Disease: Improving Global Outcomes chronic kidney disease (CKD) guidelines recommend that CKD be classified based on the etiology, glomerular filtration rate (GFR) and degree of albuminuria. The present study aimed to establish a method that predicts the presence of microalbuminuria by measuring the total urine protein-to-creatinine ratio (TPCR) in patients with cardiovascular disease (CVD) risk factors. METHODS AND RESULTS: We obtained urine samples from 1,033 patients who visited the cardiovascular clinic at St. Luke's International Hospital from February 2012 to August 2012. We measured the TPCR and the urine albumin-to-creatinine ratio (ACR) from random spot urine samples. We performed correlation, receiver operating characteristic (ROC) curve, sensitivity, and subgroup analyses. There was a strong positive correlation between the TPCR and ACR (R(2) = 0.861, p<0.001). A ROC curve analysis for the TPCR revealed a sensitivity of 94.4%, a specificity of 86.1%, and an area under the curve of 0.903 for detecting microalbuminuria for a TPCR cut-off value of 84 mg/g of creatinine. The subgroup analysis indicated that the cut-off value could be used for patients with CVD risk factors. CONCLUSIONS: These results suggest that the TPCR with an appropriate cut-off value could be used to screen for the presence of microalbuminuria in patients with CVD risk factors. This simple, inexpensive measurement has broader applications, leading to earlier intervention and public benefit. Public Library of Science 2014-03-10 /pmc/articles/PMC3948741/ /pubmed/24614247 http://dx.doi.org/10.1371/journal.pone.0091067 Text en © 2014 Yamamoto et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yamamoto, Kyoko
Yamamoto, Hiroyuki
Yoshida, Katsumi
Niwa, Koichiro
Nishi, Yutaro
Mizuno, Atsushi
Kuwabara, Masanari
Asano, Taku
Sakoda, Kunihiro
Niinuma, Hiroyuki
Nakahara, Fumiko
Takeda, Kyoko
Shindoh, Chiyohiko
Komatsu, Yasuhiro
The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria
title The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria
title_full The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria
title_fullStr The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria
title_full_unstemmed The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria
title_short The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria
title_sort total urine protein-to-creatinine ratio can predict the presence of microalbuminuria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948741/
https://www.ncbi.nlm.nih.gov/pubmed/24614247
http://dx.doi.org/10.1371/journal.pone.0091067
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