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Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis

Sympathetic hyperactivity induces adverse effects in myocardial. Recent studies have shown that exercise training induces cardioprotection against sympathetic overload; however, relevant mechanisms of this issue remain unclear. We analyzed whether exercise can prevent pathological hypertrophy induce...

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Autores principales: Silva, José Antônio, Santana, Eduardo Tadeu, Manchini, Martha Trindade, Antônio, Ednei Luis, Bocalini, Danilo Sales, Krieger, José Eduardo, Tucci, Paulo José Ferreira, Serra, Andrey Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948752/
https://www.ncbi.nlm.nih.gov/pubmed/24614810
http://dx.doi.org/10.1371/journal.pone.0091017
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author Silva, José Antônio
Santana, Eduardo Tadeu
Manchini, Martha Trindade
Antônio, Ednei Luis
Bocalini, Danilo Sales
Krieger, José Eduardo
Tucci, Paulo José Ferreira
Serra, Andrey Jorge
author_facet Silva, José Antônio
Santana, Eduardo Tadeu
Manchini, Martha Trindade
Antônio, Ednei Luis
Bocalini, Danilo Sales
Krieger, José Eduardo
Tucci, Paulo José Ferreira
Serra, Andrey Jorge
author_sort Silva, José Antônio
collection PubMed
description Sympathetic hyperactivity induces adverse effects in myocardial. Recent studies have shown that exercise training induces cardioprotection against sympathetic overload; however, relevant mechanisms of this issue remain unclear. We analyzed whether exercise can prevent pathological hypertrophy induced by sympathetic hyperactivity with modulation of the kallikrein-kinin and angiogenesis pathways. Male Wistar rats were assigned to non-trained group that received vehicle; non-trained isoproterenol treated group (Iso, 0.3 mg kg(−1) day(−1)); and trained group (Iso+Exe) which was subjected to sympathetic hyperactivity with isoproterenol. The Iso rats showed hypertrophy and myocardial dysfunction with reduced force development and relaxation of muscle. The isoproterenol induced severe fibrosis, apoptosis and reduced myocardial capillary. Interestingly, exercise blunted hypertrophy, myocardial dysfunction, fibrosis, apoptosis and capillary decreases. The sympathetic hyperactivity was associated with high abundance of ANF mRNA and β-MHC mRNA, which was significantly attenuated by exercise. The tissue kallikrein was augmented in the Iso+Exe group, and kinin B(1) receptor mRNA was increased in the Iso group. Moreover, exercise induced an increase of kinin B(2) receptor mRNA in myocardial. The myocardial content of eNOS, VEGF, VEGF receptor 2, pAkt and Bcl-2 were increased in the Iso+Exe group. Likewise, increased expression of pro-apoptotic Bad in the Iso rats was prevented by prior exercise. Our results represent the first demonstration that exercise can modulate kallikrein-kinin and angiogenesis pathways in the myocardial on sympathetic hyperactivity. These findings suggest that kallikrein-kinin and angiogenesis may have a key role in protecting the heart.
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spelling pubmed-39487522014-03-13 Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis Silva, José Antônio Santana, Eduardo Tadeu Manchini, Martha Trindade Antônio, Ednei Luis Bocalini, Danilo Sales Krieger, José Eduardo Tucci, Paulo José Ferreira Serra, Andrey Jorge PLoS One Research Article Sympathetic hyperactivity induces adverse effects in myocardial. Recent studies have shown that exercise training induces cardioprotection against sympathetic overload; however, relevant mechanisms of this issue remain unclear. We analyzed whether exercise can prevent pathological hypertrophy induced by sympathetic hyperactivity with modulation of the kallikrein-kinin and angiogenesis pathways. Male Wistar rats were assigned to non-trained group that received vehicle; non-trained isoproterenol treated group (Iso, 0.3 mg kg(−1) day(−1)); and trained group (Iso+Exe) which was subjected to sympathetic hyperactivity with isoproterenol. The Iso rats showed hypertrophy and myocardial dysfunction with reduced force development and relaxation of muscle. The isoproterenol induced severe fibrosis, apoptosis and reduced myocardial capillary. Interestingly, exercise blunted hypertrophy, myocardial dysfunction, fibrosis, apoptosis and capillary decreases. The sympathetic hyperactivity was associated with high abundance of ANF mRNA and β-MHC mRNA, which was significantly attenuated by exercise. The tissue kallikrein was augmented in the Iso+Exe group, and kinin B(1) receptor mRNA was increased in the Iso group. Moreover, exercise induced an increase of kinin B(2) receptor mRNA in myocardial. The myocardial content of eNOS, VEGF, VEGF receptor 2, pAkt and Bcl-2 were increased in the Iso+Exe group. Likewise, increased expression of pro-apoptotic Bad in the Iso rats was prevented by prior exercise. Our results represent the first demonstration that exercise can modulate kallikrein-kinin and angiogenesis pathways in the myocardial on sympathetic hyperactivity. These findings suggest that kallikrein-kinin and angiogenesis may have a key role in protecting the heart. Public Library of Science 2014-03-10 /pmc/articles/PMC3948752/ /pubmed/24614810 http://dx.doi.org/10.1371/journal.pone.0091017 Text en © 2014 Silva Jr http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Silva, José Antônio
Santana, Eduardo Tadeu
Manchini, Martha Trindade
Antônio, Ednei Luis
Bocalini, Danilo Sales
Krieger, José Eduardo
Tucci, Paulo José Ferreira
Serra, Andrey Jorge
Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis
title Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis
title_full Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis
title_fullStr Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis
title_full_unstemmed Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis
title_short Exercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesis
title_sort exercise training can prevent cardiac hypertrophy induced by sympathetic hyperactivity with modulation of kallikrein-kinin pathway and angiogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948752/
https://www.ncbi.nlm.nih.gov/pubmed/24614810
http://dx.doi.org/10.1371/journal.pone.0091017
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