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A Bayesian MCMC Approach to Assess the Complete Distribution of Fitness Effects of New Mutations: Uncovering the Potential for Adaptive Walks in Challenging Environments

The role of adaptation in the evolutionary process has been contentious for decades. At the heart of the century-old debate between neutralists and selectionists lies the distribution of fitness effects (DFE)—that is, the selective effect of all mutations. Attempts to describe the DFE have been vari...

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Detalles Bibliográficos
Autores principales:	Bank, Claudia, Hietpas, Ryan T., Wong, Alex, Bolon, Daniel N., Jensen, Jeffrey D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2014
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948810/ https://www.ncbi.nlm.nih.gov/pubmed/24398421 http://dx.doi.org/10.1534/genetics.113.156190

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