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Ubiquitination and Degradation of Ribonucleotide Reductase M1 by the Polycomb Group Proteins RNF2 and Bmi1 and Cellular Response to Gemcitabine

Ribonucleotide reductase M1 (RRM1) is required for mammalian deoxyribonucleotide (dNTP) metabolism. It is the primary target of the antimetabolite drug gemcitabine, which is among the most efficacious and most widely used cancer therapeutics. Gemcitabine directly binds to RRM1 and irreversibly inact...

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Detalles Bibliográficos
Autores principales:	Zhang, Yingtao, Li, Xin, Chen, Zhengming, Bepler, Gerold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948819/ https://www.ncbi.nlm.nih.gov/pubmed/24614341 http://dx.doi.org/10.1371/journal.pone.0091186

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