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Selectivity and Potency of Microcystin Congeners against OATP1B1 and OATP1B3 Expressing Cancer Cells

Microcystins are potent phosphatase inhibitors and cellular toxins. They require active transport by OATP1B1 and OATP1B3 transporters for uptake into human cells, and the high expression of these transporters in the liver accounts for their selective hepatic toxicity. Several human tumors have been...

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Detalles Bibliográficos
Autores principales:	Niedermeyer, Timo H. J., Daily, Abigail, Swiatecka-Hagenbruch, Monika, Moscow, Jeffrey A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948918/ https://www.ncbi.nlm.nih.gov/pubmed/24614281 http://dx.doi.org/10.1371/journal.pone.0091476

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