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Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine

Thioredoxin reductase (TR) catalyzes the reduction of thioredoxin (TRX), which in turn reduces mammalian typical 2-Cys peroxiredoxins (PRXs 1–4), thiol peroxidases implicated in redox homeostasis and cell signaling. Typical 2-Cys PRXs are inactivated by hyperoxidation of the peroxidatic cysteine to...

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Detalles Bibliográficos
Autores principales:	Cunniff, Brian, Snider, Gregg W., Fredette, Nicholas, Stumpff, Jason, Hondal, Robert J., Heintz, Nicholas H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949094/ https://www.ncbi.nlm.nih.gov/pubmed/24624337 http://dx.doi.org/10.1016/j.redox.2014.01.021

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