Cargando…
Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+)()
With the goal to enhance the distribution of cationic Mn porphyrins within mitochondria, the lipophilic Mn(III)meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) has been synthesized and tested in several different model of diseases, where it shows remarkable efficacy at as low as 5...
Autores principales: | Gauter-Fleckenstein, Benjamin, Reboucas, Julio S., Fleckenstein, Katharina, Tovmasyan, Artak, Owzar, Kouros, Jiang, Chen, Batinic-Haberle, Ines, Vujaskovic, Zeljko |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949096/ https://www.ncbi.nlm.nih.gov/pubmed/24624330 http://dx.doi.org/10.1016/j.redox.2013.12.017 |
Ejemplares similares
-
Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP(4+), in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H(2)O)MnTnHex-2-PyP(5+)
por: Li, Litao, et al.
Publicado: (2020) -
Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP(5+), Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation
por: Cline, John Mark, et al.
Publicado: (2018) -
The SOD Mimic MnTnHex-2-PyP(5+) Reduces the Viability and Migration of 786-O Human Renal Cancer Cells
por: Costa, João G., et al.
Publicado: (2019) -
MnTnHex-2-PyP(5+) Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells
por: Soares, Rita B., et al.
Publicado: (2022) -
The manganese(III) porphyrin MnTnHex-2-PyP(5+) modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells
por: Flórido, Ana, et al.
Publicado: (2018)