Rejuvenation of the aged muscle stem cell population restores strength to injured aged muscles

The aged suffer from progressive muscle weakness and regenerative failure. We demonstrate that muscle regeneration is impaired with aging due in part to a cell-autonomous functional decline in skeletal muscle stem cells (MuSCs). Two-thirds of aged MuSCs are intrinsically defective relative to young...

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Detalles Bibliográficos
Autores principales: Cosgrove, Benjamin D., Gilbert, Penney M., Porpiglia, Ermelinda, Mourkioti, Foteini, Lee, Steven P., Corbel, Stephane Y., Llewellyn, Michael E., Delp, Scott L., Blau, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949152/
https://www.ncbi.nlm.nih.gov/pubmed/24531378
http://dx.doi.org/10.1038/nm.3464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949152/
https://www.ncbi.nlm.nih.gov/pubmed/24531378
http://dx.doi.org/10.1038/nm.3464

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