Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides

Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search...

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Detalles Bibliográficos
Autores principales: Lomas, Oliver, Zaccolo, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949206/
https://www.ncbi.nlm.nih.gov/pubmed/24583770
http://dx.doi.org/10.1152/physiol.00040.2013
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author Lomas, Oliver
Zaccolo, Manuela
author_facet Lomas, Oliver
Zaccolo, Manuela
author_sort Lomas, Oliver
collection PubMed
description Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.
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spelling pubmed-39492062014-08-06 Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides Lomas, Oliver Zaccolo, Manuela Physiology (Bethesda) Reviews Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments. American Physiological Society 2014-03 /pmc/articles/PMC3949206/ /pubmed/24583770 http://dx.doi.org/10.1152/physiol.00040.2013 Text en ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc. Licensed under Creative Commons Attribution CC-BY 3.0 (http://creativecommons.org/licenses/by/3.0/deed.en_US) : the American Physiological Society.
spellingShingle Reviews
Lomas, Oliver
Zaccolo, Manuela
Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides
title Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides
title_full Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides
title_fullStr Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides
title_full_unstemmed Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides
title_short Phosphodiesterases Maintain Signaling Fidelity via Compartmentalization of Cyclic Nucleotides
title_sort phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949206/
https://www.ncbi.nlm.nih.gov/pubmed/24583770
http://dx.doi.org/10.1152/physiol.00040.2013
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