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An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system
What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949298/ https://www.ncbi.nlm.nih.gov/pubmed/24613915 http://dx.doi.org/10.1038/srep04335 |
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author | Yoshida, Hiroshi Bando, Tetsuya Mito, Taro Ohuchi, Hideyo Noji, Sumihare |
author_facet | Yoshida, Hiroshi Bando, Tetsuya Mito, Taro Ohuchi, Hideyo Noji, Sumihare |
author_sort | Yoshida, Hiroshi |
collection | PubMed |
description | What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination. |
format | Online Article Text |
id | pubmed-3949298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-39492982014-03-12 An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system Yoshida, Hiroshi Bando, Tetsuya Mito, Taro Ohuchi, Hideyo Noji, Sumihare Sci Rep Article What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination. Nature Publishing Group 2014-03-11 /pmc/articles/PMC3949298/ /pubmed/24613915 http://dx.doi.org/10.1038/srep04335 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Yoshida, Hiroshi Bando, Tetsuya Mito, Taro Ohuchi, Hideyo Noji, Sumihare An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system |
title | An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system |
title_full | An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system |
title_fullStr | An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system |
title_full_unstemmed | An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system |
title_short | An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system |
title_sort | extended steepness model for leg-size determination based on dachsous/fat trans-dimer system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949298/ https://www.ncbi.nlm.nih.gov/pubmed/24613915 http://dx.doi.org/10.1038/srep04335 |
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