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p53 activity is selectively licensed in the Drosophila stem cell compartment

Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after exposure to stressors that destabilize the genome. Si...

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Detalles Bibliográficos
Autores principales:	Wylie, Annika, Lu, Wan-Jin, D’Brot, Alejandro, Buszczak, Michael, Abrams, John M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Developmental Biology and Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949305/ https://www.ncbi.nlm.nih.gov/pubmed/24618896 http://dx.doi.org/10.7554/eLife.01530

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