Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here that PP2A-B55 is the enzyme responsible for dephospho...

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Detalles Bibliográficos
Autores principales: Williams, Byron C, Filter, Joshua J, Blake-Hodek, Kristina A, Wadzinski, Brian E, Fuda, Nicholas J, Shalloway, David, Goldberg, Michael L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949306/
https://www.ncbi.nlm.nih.gov/pubmed/24618897
http://dx.doi.org/10.7554/eLife.01695

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