Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution

The enzyme porphobilinogen deaminase (PBGD; hydroxymethylbilane synthase; EC 2.5.1.61) catalyses an early step of the tetrapyrrole-biosynthesis pathway in which four molecules of the monopyrrole porphobilinogen are condensed to form a linear tetrapyrrole. The enzyme possesses a dipyrromethane cofact...

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Detalles Bibliográficos
Autores principales: Azim, N., Deery, E., Warren, M. J., Wolfenden, B. A. A., Erskine, P., Cooper, J. B., Coker, A., Wood, S. P., Akhtar, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949521/
https://www.ncbi.nlm.nih.gov/pubmed/24598743
http://dx.doi.org/10.1107/S139900471303294X

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