Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2

Recruitment of circulating leukocytes into inflamed tissues depends on adhesion molecules expressed by endothelial cells (ECs). Here we report that rapamycin pretreatment reduced the ability of TNF-treated ECs to capture T cells under conditions of venular flow. This functional change was caused by...

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Detalles Bibliográficos
Autores principales: Wang, Chen, Qin, Lingfeng, Manes, Thomas D., Kirkiles-Smith, Nancy C., Tellides, George, Pober, Jordan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949571/
https://www.ncbi.nlm.nih.gov/pubmed/24516119
http://dx.doi.org/10.1084/jem.20131125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949571/
https://www.ncbi.nlm.nih.gov/pubmed/24516119
http://dx.doi.org/10.1084/jem.20131125

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