Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication

Pharmacological targeting of metabolic processes in cancer must overcome redundancy in biosynthetic pathways. Deoxycytidine (dC) triphosphate (dCTP) can be produced both by the de novo pathway (DNP) and by the nucleoside salvage pathway (NSP). However, the role of the NSP in dCTP production and DNA...

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Detalles Bibliográficos
Autores principales: Nathanson, David A., Armijo, Amanda L., Tom, Michelle, Li, Zheng, Dimitrova, Elizabeth, Austin, Wayne R., Nomme, Julian, Campbell, Dean O., Ta, Lisa, Le, Thuc M., Lee, Jason T., Darvish, Ryan, Gordin, Ari, Wei, Liu, Liao, Hsiang-I, Wilks, Moses, Martin, Colette, Sadeghi, Saman, Murphy, Jennifer M., Boulos, Nidal, Phelps, Michael E., Faull, Kym F., Herschman, Harvey R., Jung, Michael E., Czernin, Johannes, Lavie, Arnon, Radu, Caius G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949575/
https://www.ncbi.nlm.nih.gov/pubmed/24567448
http://dx.doi.org/10.1084/jem.20131738

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