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Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study
Structural and functional features of various cerebral cortices have been extensively explored in neuroscience research. We used manganese-enhanced MRI, a non-invasive method for examining stimulus-dependent activity in the whole brain, to investigate the activity in the layers of primary cortices a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949704/ https://www.ncbi.nlm.nih.gov/pubmed/24618696 http://dx.doi.org/10.1371/journal.pone.0090427 |
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author | Kim, Hyungjun Cho, Junghun Kim, Young R. Song, Youngkyu Chun, Song-I Suh, Ji-Yeon Kim, Jeong Kon Ryu, Yeon-Hee Choi, Sun-Mi Cho, Hyungjoon Cho, Gyunggoo |
author_facet | Kim, Hyungjun Cho, Junghun Kim, Young R. Song, Youngkyu Chun, Song-I Suh, Ji-Yeon Kim, Jeong Kon Ryu, Yeon-Hee Choi, Sun-Mi Cho, Hyungjoon Cho, Gyunggoo |
author_sort | Kim, Hyungjun |
collection | PubMed |
description | Structural and functional features of various cerebral cortices have been extensively explored in neuroscience research. We used manganese-enhanced MRI, a non-invasive method for examining stimulus-dependent activity in the whole brain, to investigate the activity in the layers of primary cortices and sensory, such as auditory and olfactory, pathways under acoustic stimulation. Male Sprague-Dawley rats, either with or without exposure to auditory stimulation, were scanned before and 24–29 hour after systemic MnCl(2) injection. Cortex linearization and layer-dependent signal extraction were subsequently performed for detecting layer-specific cortical activity. We found stimulus-dependent activity in the deep layers of the primary auditory cortex and the auditory pathways. The primary sensory and visual cortices also showed the enhanced activity, whereas the olfactory pathways did not. Further, we performed correlation analysis of the signal intensity ratios among different layers of each cortex, and compared the strength of correlations between with and without the auditory stimulation. In the primary auditory cortex, the correlation strength between left and right hemisphere showed a slight but not significant increase with the acoustic simulation, whereas, in the primary sensory and visual cortex, the correlation coefficients were significantly smaller. These results suggest the possibility that even though the primary auditory, sensory, and visual cortices showed enhanced activity to the auditory stimulation, these cortices had different associations for auditory processing in the brain network. |
format | Online Article Text |
id | pubmed-3949704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39497042014-03-12 Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study Kim, Hyungjun Cho, Junghun Kim, Young R. Song, Youngkyu Chun, Song-I Suh, Ji-Yeon Kim, Jeong Kon Ryu, Yeon-Hee Choi, Sun-Mi Cho, Hyungjoon Cho, Gyunggoo PLoS One Research Article Structural and functional features of various cerebral cortices have been extensively explored in neuroscience research. We used manganese-enhanced MRI, a non-invasive method for examining stimulus-dependent activity in the whole brain, to investigate the activity in the layers of primary cortices and sensory, such as auditory and olfactory, pathways under acoustic stimulation. Male Sprague-Dawley rats, either with or without exposure to auditory stimulation, were scanned before and 24–29 hour after systemic MnCl(2) injection. Cortex linearization and layer-dependent signal extraction were subsequently performed for detecting layer-specific cortical activity. We found stimulus-dependent activity in the deep layers of the primary auditory cortex and the auditory pathways. The primary sensory and visual cortices also showed the enhanced activity, whereas the olfactory pathways did not. Further, we performed correlation analysis of the signal intensity ratios among different layers of each cortex, and compared the strength of correlations between with and without the auditory stimulation. In the primary auditory cortex, the correlation strength between left and right hemisphere showed a slight but not significant increase with the acoustic simulation, whereas, in the primary sensory and visual cortex, the correlation coefficients were significantly smaller. These results suggest the possibility that even though the primary auditory, sensory, and visual cortices showed enhanced activity to the auditory stimulation, these cortices had different associations for auditory processing in the brain network. Public Library of Science 2014-03-11 /pmc/articles/PMC3949704/ /pubmed/24618696 http://dx.doi.org/10.1371/journal.pone.0090427 Text en © 2014 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kim, Hyungjun Cho, Junghun Kim, Young R. Song, Youngkyu Chun, Song-I Suh, Ji-Yeon Kim, Jeong Kon Ryu, Yeon-Hee Choi, Sun-Mi Cho, Hyungjoon Cho, Gyunggoo Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study |
title | Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study |
title_full | Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study |
title_fullStr | Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study |
title_full_unstemmed | Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study |
title_short | Response of the Primary Auditory and Non-Auditory Cortices to Acoustic Stimulation: A Manganese-Enhanced MRI Study |
title_sort | response of the primary auditory and non-auditory cortices to acoustic stimulation: a manganese-enhanced mri study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949704/ https://www.ncbi.nlm.nih.gov/pubmed/24618696 http://dx.doi.org/10.1371/journal.pone.0090427 |
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