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A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

Despite recent progress, the physiological role of Hippo signaling in mammary gland development and tumorigenesis remains poorly understood. Here we show that the Hippo pathway is functionally dispensable in virgin mammary glands but specifically required during pregnancy. In contrast to many other...

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Detalles Bibliográficos
Autores principales: Chen, Qian, Zhang, Nailing, Gray, Ryan S., Li, Huili, Ewald, Andrew J., Zahnow, Cynthia A., Pan, Duojia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950341/
https://www.ncbi.nlm.nih.gov/pubmed/24589775
http://dx.doi.org/10.1101/gad.233676.113