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The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

The Mre11 complex (Mre11, Rad50, and Nbs1) is a central component of the DNA damage response (DDR), governing both double-strand break repair and DDR signaling. Rad50 contains a highly conserved Zn(2+)-dependent homodimerization interface, the Rad50 hook domain. Mutations that inactivate the hook do...

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Detalles Bibliográficos
Autores principales:	Roset, Ramon, Inagaki, Akiko, Hohl, Marcel, Brenet, Fabienne, Lafrance-Vanasse, Julien, Lange, Julian, Scandura, Joseph M., Tainer, John A., Keeney, Scott, Petrini, John H.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950343/ https://www.ncbi.nlm.nih.gov/pubmed/24532689 http://dx.doi.org/10.1101/gad.236745.113

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