Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes

Nowadays diabetes is one of the most common metabolic diseases. Sphingolipids, which are vitally important constituents of intracellular signal transduction pathways, may be among the most pathogenic lipid moieties intermingled in the origin and development of diabetes. It is now well established th...

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Autores principales: Kurek, Krzysztof, Wiesiołek-Kurek, Patrycja, Piotrowska, Dominika M., Łukaszuk, Bartłomiej, Chabowski, Adrian, Żendzian-Piotrowska, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950399/
https://www.ncbi.nlm.nih.gov/pubmed/24701589
http://dx.doi.org/10.1155/2014/980815
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author Kurek, Krzysztof
Wiesiołek-Kurek, Patrycja
Piotrowska, Dominika M.
Łukaszuk, Bartłomiej
Chabowski, Adrian
Żendzian-Piotrowska, Małgorzata
author_facet Kurek, Krzysztof
Wiesiołek-Kurek, Patrycja
Piotrowska, Dominika M.
Łukaszuk, Bartłomiej
Chabowski, Adrian
Żendzian-Piotrowska, Małgorzata
author_sort Kurek, Krzysztof
collection PubMed
description Nowadays diabetes is one of the most common metabolic diseases. Sphingolipids, which are vitally important constituents of intracellular signal transduction pathways, may be among the most pathogenic lipid moieties intermingled in the origin and development of diabetes. It is now well established that inhibition of de novo ceramide synthesis with myriocin exerts positive effects on lipid metabolism and glucose homeostasis in type 2 diabetes mellitus animal models. However, its influence on type I diabetes still remains unknown. Therefore, the scope of this paper is to fulfill that particular gap in our knowledge.
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spelling pubmed-39503992014-04-03 Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes Kurek, Krzysztof Wiesiołek-Kurek, Patrycja Piotrowska, Dominika M. Łukaszuk, Bartłomiej Chabowski, Adrian Żendzian-Piotrowska, Małgorzata Biomed Res Int Research Article Nowadays diabetes is one of the most common metabolic diseases. Sphingolipids, which are vitally important constituents of intracellular signal transduction pathways, may be among the most pathogenic lipid moieties intermingled in the origin and development of diabetes. It is now well established that inhibition of de novo ceramide synthesis with myriocin exerts positive effects on lipid metabolism and glucose homeostasis in type 2 diabetes mellitus animal models. However, its influence on type I diabetes still remains unknown. Therefore, the scope of this paper is to fulfill that particular gap in our knowledge. Hindawi Publishing Corporation 2014 2014-02-19 /pmc/articles/PMC3950399/ /pubmed/24701589 http://dx.doi.org/10.1155/2014/980815 Text en Copyright © 2014 Krzysztof Kurek et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kurek, Krzysztof
Wiesiołek-Kurek, Patrycja
Piotrowska, Dominika M.
Łukaszuk, Bartłomiej
Chabowski, Adrian
Żendzian-Piotrowska, Małgorzata
Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes
title Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes
title_full Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes
title_fullStr Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes
title_full_unstemmed Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes
title_short Inhibition of Ceramide De Novo Synthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes
title_sort inhibition of ceramide de novo synthesis with myriocin affects lipid metabolism in the liver of rats with streptozotocin-induced type 1 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950399/
https://www.ncbi.nlm.nih.gov/pubmed/24701589
http://dx.doi.org/10.1155/2014/980815
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