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Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion
BACKGROUND: Severe bleeding is common during limb trauma. It can lead to hemorrhagic shock required to massive blood transfusion. Coagulopathy is the major complication of massive transfusion-induced increased mortality rate. Aim of this study was evaluation of fibrinogen and albumin levels associat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950447/ https://www.ncbi.nlm.nih.gov/pubmed/24665235 http://dx.doi.org/10.4103/1658-354X.125915 |
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author | Bazavar, Mohammadreza Tabrizi, Ali Abedini, Naghi Elmi, Asghar |
author_facet | Bazavar, Mohammadreza Tabrizi, Ali Abedini, Naghi Elmi, Asghar |
author_sort | Bazavar, Mohammadreza |
collection | PubMed |
description | BACKGROUND: Severe bleeding is common during limb trauma. It can lead to hemorrhagic shock required to massive blood transfusion. Coagulopathy is the major complication of massive transfusion-induced increased mortality rate. Aim of this study was evaluation of fibrinogen and albumin levels association with orthopedics traumatic patients’ outcome who received massive transfusion. METHODS: In a cross sectional study, 23 patients with severe limb injury admitted to orthopedic emergency department were studied. All the patients received massive transfusion, that is, >10 unit blood. Albumin and fibrinogen levels are measured at admission and 24 h later, and compared according to final outcome. RESULTS: Twenty-three traumatic patients with severe limb injuries were studied, out of which ten (43.2%) died and 13 (56.8%) were alive. There was significant difference between patients outcome in fibrinogen level after 24 h, but no difference was observed in albumin levels. Based on regression model, fibrinogen after 24 h had a significant role in determining the final outcome in traumatic patients who received massive transfusion (odds ratio 0.48, 95% confidence interval 0.15–0.92, P = 0.02). CONCLUSIONS: According to our results, fibrinogen level is the most important factor in determination of orthopedics traumatic patients when received massive transfusion. However, serum albumin does not play any role in patients’ outcome. |
format | Online Article Text |
id | pubmed-3950447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39504472014-03-24 Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion Bazavar, Mohammadreza Tabrizi, Ali Abedini, Naghi Elmi, Asghar Saudi J Anaesth Original Article BACKGROUND: Severe bleeding is common during limb trauma. It can lead to hemorrhagic shock required to massive blood transfusion. Coagulopathy is the major complication of massive transfusion-induced increased mortality rate. Aim of this study was evaluation of fibrinogen and albumin levels association with orthopedics traumatic patients’ outcome who received massive transfusion. METHODS: In a cross sectional study, 23 patients with severe limb injury admitted to orthopedic emergency department were studied. All the patients received massive transfusion, that is, >10 unit blood. Albumin and fibrinogen levels are measured at admission and 24 h later, and compared according to final outcome. RESULTS: Twenty-three traumatic patients with severe limb injuries were studied, out of which ten (43.2%) died and 13 (56.8%) were alive. There was significant difference between patients outcome in fibrinogen level after 24 h, but no difference was observed in albumin levels. Based on regression model, fibrinogen after 24 h had a significant role in determining the final outcome in traumatic patients who received massive transfusion (odds ratio 0.48, 95% confidence interval 0.15–0.92, P = 0.02). CONCLUSIONS: According to our results, fibrinogen level is the most important factor in determination of orthopedics traumatic patients when received massive transfusion. However, serum albumin does not play any role in patients’ outcome. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3950447/ /pubmed/24665235 http://dx.doi.org/10.4103/1658-354X.125915 Text en Copyright: © Saudi Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bazavar, Mohammadreza Tabrizi, Ali Abedini, Naghi Elmi, Asghar Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion |
title | Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion |
title_full | Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion |
title_fullStr | Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion |
title_full_unstemmed | Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion |
title_short | Albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion |
title_sort | albumin and fibrinogen levels’ relation with orthopedics traumatic patients’ outcome after massive transfusion |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950447/ https://www.ncbi.nlm.nih.gov/pubmed/24665235 http://dx.doi.org/10.4103/1658-354X.125915 |
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