Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine

Through the use of genetic, enzymatic, metabolomic, and structural analyses, we have discovered the catabolic pathway for proline betaine, an osmoprotectant, in Paracoccus denitrificans and Rhodobacter sphaeroides. Genetic and enzymatic analyses showed that several of the key enzymes of the hydroxyp...

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Detalles Bibliográficos
Autores principales: Kumar, Ritesh, Zhao, Suwen, Vetting, Matthew W., Wood, B. McKay, Sakai, Ayano, Cho, Kyuil, Solbiati, José, Almo, Steven C., Sweedler, Jonathan V., Jacobson, Matthew P., Gerlt, John A., Cronan, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950512/
https://www.ncbi.nlm.nih.gov/pubmed/24520058
http://dx.doi.org/10.1128/mBio.00933-13

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