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Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies

Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with t...

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Detalles Bibliográficos
Autores principales: Nunes, Tiago, Bernardazzi, Claudio, de Souza, Heitor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950548/
https://www.ncbi.nlm.nih.gov/pubmed/24701033
http://dx.doi.org/10.1155/2014/423957
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author Nunes, Tiago
Bernardazzi, Claudio
de Souza, Heitor S.
author_facet Nunes, Tiago
Bernardazzi, Claudio
de Souza, Heitor S.
author_sort Nunes, Tiago
collection PubMed
description Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation.
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spelling pubmed-39505482014-04-03 Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies Nunes, Tiago Bernardazzi, Claudio de Souza, Heitor S. Mediators Inflamm Review Article Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation. Hindawi Publishing Corporation 2014 2014-02-20 /pmc/articles/PMC3950548/ /pubmed/24701033 http://dx.doi.org/10.1155/2014/423957 Text en Copyright © 2014 Tiago Nunes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nunes, Tiago
Bernardazzi, Claudio
de Souza, Heitor S.
Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
title Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
title_full Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
title_fullStr Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
title_full_unstemmed Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
title_short Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
title_sort interleukin-33 and inflammatory bowel diseases: lessons from human studies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950548/
https://www.ncbi.nlm.nih.gov/pubmed/24701033
http://dx.doi.org/10.1155/2014/423957
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