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Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950548/ https://www.ncbi.nlm.nih.gov/pubmed/24701033 http://dx.doi.org/10.1155/2014/423957 |
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author | Nunes, Tiago Bernardazzi, Claudio de Souza, Heitor S. |
author_facet | Nunes, Tiago Bernardazzi, Claudio de Souza, Heitor S. |
author_sort | Nunes, Tiago |
collection | PubMed |
description | Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation. |
format | Online Article Text |
id | pubmed-3950548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39505482014-04-03 Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies Nunes, Tiago Bernardazzi, Claudio de Souza, Heitor S. Mediators Inflamm Review Article Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation. Hindawi Publishing Corporation 2014 2014-02-20 /pmc/articles/PMC3950548/ /pubmed/24701033 http://dx.doi.org/10.1155/2014/423957 Text en Copyright © 2014 Tiago Nunes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nunes, Tiago Bernardazzi, Claudio de Souza, Heitor S. Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies |
title | Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies |
title_full | Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies |
title_fullStr | Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies |
title_full_unstemmed | Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies |
title_short | Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies |
title_sort | interleukin-33 and inflammatory bowel diseases: lessons from human studies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950548/ https://www.ncbi.nlm.nih.gov/pubmed/24701033 http://dx.doi.org/10.1155/2014/423957 |
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