Cargando…
NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas
Zuojin Wan (ZJW) and Lizhong Wan (LZW) have been widely used in the treatment of Stomach heat and cold syndrome (SH and SC), respectively. In this study, a proton nuclear magnetic resonance ((1)H NMR) based metabonomic approach was developed to profile SH and SC-related metabolic perturbations in ra...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950656/ https://www.ncbi.nlm.nih.gov/pubmed/24701240 http://dx.doi.org/10.1155/2014/528396 |
_version_ | 1782307025319886848 |
---|---|
author | Zou, Zhongjie Han, Bin Gong, Mengjuan Wang, Shumei Liang, Shengwang |
author_facet | Zou, Zhongjie Han, Bin Gong, Mengjuan Wang, Shumei Liang, Shengwang |
author_sort | Zou, Zhongjie |
collection | PubMed |
description | Zuojin Wan (ZJW) and Lizhong Wan (LZW) have been widely used in the treatment of Stomach heat and cold syndrome (SH and SC), respectively. In this study, a proton nuclear magnetic resonance ((1)H NMR) based metabonomic approach was developed to profile SH and SC-related metabolic perturbations in rat serum and to investigate the intervention effects of ZJW and LZW on the corresponding SH and SC. Compared to the conventional macroscopic and histopathological examinations, the metabonomic approach could enable discrimination between SH and SC based on serum metabolic profiles. Meanwhile, 17 and 15 potential biomarkers associated with SH and SC, respectively, which were mainly involved in gastric dysfunction and mucosal lesions, gut microbiotal activity, transmethylation, glucose and lipid metabolism, and amino acid metabolism, were identified. Furthermore, taking the potential biomarkers as drug targets, it was revealed that administration of ZJW and LZW could exclusively reverse the pathological process of SH and SC, respectively, through partially regulating the disturbed metabolic pathways. This work showed biological basis related to SH and SC at metabolic level and offered a new paradigm for better understanding and explanation of “Fang Zheng Dui Ying” principle in traditional Chinese medicine from a systemic view. |
format | Online Article Text |
id | pubmed-3950656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39506562014-04-03 NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas Zou, Zhongjie Han, Bin Gong, Mengjuan Wang, Shumei Liang, Shengwang Evid Based Complement Alternat Med Research Article Zuojin Wan (ZJW) and Lizhong Wan (LZW) have been widely used in the treatment of Stomach heat and cold syndrome (SH and SC), respectively. In this study, a proton nuclear magnetic resonance ((1)H NMR) based metabonomic approach was developed to profile SH and SC-related metabolic perturbations in rat serum and to investigate the intervention effects of ZJW and LZW on the corresponding SH and SC. Compared to the conventional macroscopic and histopathological examinations, the metabonomic approach could enable discrimination between SH and SC based on serum metabolic profiles. Meanwhile, 17 and 15 potential biomarkers associated with SH and SC, respectively, which were mainly involved in gastric dysfunction and mucosal lesions, gut microbiotal activity, transmethylation, glucose and lipid metabolism, and amino acid metabolism, were identified. Furthermore, taking the potential biomarkers as drug targets, it was revealed that administration of ZJW and LZW could exclusively reverse the pathological process of SH and SC, respectively, through partially regulating the disturbed metabolic pathways. This work showed biological basis related to SH and SC at metabolic level and offered a new paradigm for better understanding and explanation of “Fang Zheng Dui Ying” principle in traditional Chinese medicine from a systemic view. Hindawi Publishing Corporation 2014 2014-02-20 /pmc/articles/PMC3950656/ /pubmed/24701240 http://dx.doi.org/10.1155/2014/528396 Text en Copyright © 2014 Zhongjie Zou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zou, Zhongjie Han, Bin Gong, Mengjuan Wang, Shumei Liang, Shengwang NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas |
title | NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas |
title_full | NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas |
title_fullStr | NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas |
title_full_unstemmed | NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas |
title_short | NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas |
title_sort | nmr-based metabonomic studies on stomach heat and cold syndromes and intervention effects of the corresponding formulas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950656/ https://www.ncbi.nlm.nih.gov/pubmed/24701240 http://dx.doi.org/10.1155/2014/528396 |
work_keys_str_mv | AT zouzhongjie nmrbasedmetabonomicstudiesonstomachheatandcoldsyndromesandinterventioneffectsofthecorrespondingformulas AT hanbin nmrbasedmetabonomicstudiesonstomachheatandcoldsyndromesandinterventioneffectsofthecorrespondingformulas AT gongmengjuan nmrbasedmetabonomicstudiesonstomachheatandcoldsyndromesandinterventioneffectsofthecorrespondingformulas AT wangshumei nmrbasedmetabonomicstudiesonstomachheatandcoldsyndromesandinterventioneffectsofthecorrespondingformulas AT liangshengwang nmrbasedmetabonomicstudiesonstomachheatandcoldsyndromesandinterventioneffectsofthecorrespondingformulas |