Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N(2)-dG adduct in the NarI DNA recognition sequence

2-Amino-3-methylimidazo[4,5-f]quinolone (IQ), a heterocyclic amine found in cooked meats, undergoes bioactivation to a nitrenium ion, which alkylates guanines at both the C8-dG and N(2)-dG positions. The conformation of a site-specific N(2)-dG-IQ adduct in an oligodeoxynucleotide duplex containing t...

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Detalles Bibliográficos
Autores principales: Stavros, Kallie M., Hawkins, Edward K., Rizzo, Carmelo J., Stone, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950664/
https://www.ncbi.nlm.nih.gov/pubmed/24366876
http://dx.doi.org/10.1093/nar/gkt1109

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