Cargando…

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei

Monoallelic expression within a gene family is found in pathogens exhibiting antigenic variation and in mammalian olfactory neurons. Trypanosoma brucei, a lethal parasite living in the human bloodstream, expresses variant surface glycoprotein (VSG) from 1 of 15 bloodstream expression sites (BESs) by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Tu N., Müller, Laura S. M., Park, Sung Hee, Siegel, T. Nicolai, Günzl, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950698/ https://www.ncbi.nlm.nih.gov/pubmed/24353315 http://dx.doi.org/10.1093/nar/gkt1301

Ejemplares similares

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei
por: Mugnier, Monica R., et al.
Publicado: (2016)

Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei
por: Landeira, David, et al.
Publicado: (2007)

NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei
por: Narayanan, Mani Shankar, et al.
Publicado: (2011)

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity
por: Cordon-Obras, Carlos, et al.
Publicado: (2013)

Well-positioned nucleosomes punctuate polycistronic pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei
por: Maree, Johannes Petrus, et al.
Publicado: (2017)

Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum
por: Young, Rosanna, et al.
Publicado: (2008)

TOPO3α Influences Antigenic Variation by Monitoring Expression-Site-Associated VSG Switching in Trypanosoma brucei
por: Kim, Hee-Sook, et al.
Publicado: (2010)

Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei
por: Povelones, Megan L., et al.
Publicado: (2012)

FACT plays a major role in histone dynamics affecting VSG expression site control in Trypanosoma brucei
por: Denninger, Viola, et al.
Publicado: (2014)

Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei
por: Budzak, James, et al.
Publicado: (2019)

The FACT subunit TbSpt16 is involved in cell cycle specific control of VSG expression sites in Trypanosoma brucei
por: Denninger, Viola, et al.
Publicado: (2010)

Trypanosoma brucei Interaction with Host: Mechanism of VSG Release as Target for Drug Discovery for African Trypanosomiasis
por: Moreno, Cláudia Jassica Gonçalves, et al.
Publicado: (2019)

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms
por: Jehi, Sanaa E., et al.
Publicado: (2016)

VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei
por: Tihon, Eliane, et al.
Publicado: (2022)

A TFIIB-like protein is indispensable for spliced leader RNA gene transcription in Trypanosoma brucei
por: Schimanski, Bernd, et al.
Publicado: (2006)

A TFIIB-like protein is indispensable for spliced leader RNA gene transcription in Trypanosoma brucei
por: Schimanski, Bernd, et al.
Publicado: (2006)

Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity
por: Jehi, Sanaa E., et al.
Publicado: (2014)

The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice
por: Magez, Stefan, et al.
Publicado: (2008)

SUMOylation by the E3 Ligase TbSIZ1/PIAS1 Positively Regulates VSG Expression in Trypanosoma brucei
por: López-Farfán, Diana, et al.
Publicado: (2014)

Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity
por: Castillo-Acosta, Víctor M., et al.
Publicado: (2015)

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei
por: Alsford, Sam, et al.
Publicado: (2012)

An RNA polymerase II-associated TFIIF-like complex is indispensable for SL RNA gene transcription in Trypanosoma brucei
por: Srivastava, Ankita, et al.
Publicado: (2018)

Three dimensional organisation of basal bodies in Trypanosoma brucei
por: Towers, K, et al.
Publicado: (2012)

Transcriptionally active TFIIH of the early-diverged eukaryote Trypanosoma brucei harbors two novel core subunits but not a cyclin-activating kinase complex
por: Lee, Ju Huck, et al.
Publicado: (2009)

Identification of a Novel Chromosomal Passenger Complex and Its Unique Localization during Cytokinesis in Trypanosoma brucei
por: Li, Ziyin, et al.
Publicado: (2008)

U1 small nuclear RNP from Trypanosoma brucei: a minimal U1 snRNA with unusual protein components
por: Palfi, Zsofia, et al.
Publicado: (2005)

Basal Body Positioning Is Controlled by Flagellum Formation in Trypanosoma brucei
por: Absalon, Sabrina, et al.
Publicado: (2007)

MCM-BP Is Required for Repression of Life-Cycle Specific Genes Transcribed by RNA Polymerase I in the Mammalian Infectious Form of Trypanosoma brucei
por: Kim, Hee-Sook, et al.
Publicado: (2013)

High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis
por: Stijlemans, Benoît, et al.
Publicado: (2011)

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression
por: Gaurav, Amit Kumar, et al.
Publicado: (2023)

Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites
por: Siegel, Tim Nicolai, et al.
Publicado: (2010)

Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei
por: Vaughan, Sue, et al.
Publicado: (2016)

VSG mRNA levels are regulated by the production of functional VSG protein
por: Maudlin, Isabella E., et al.
Publicado: (2021)

Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei
por: Hertz-Fowler, Christiane, et al.
Publicado: (2008)

Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei
por: Ramakrishnan, Srinivasan, et al.
Publicado: (2018)

Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma brucei
por: Reynolds, David, et al.
Publicado: (2014)

SUMOylation in Trypanosoma brucei
por: Klein, Cornelia Andrea, et al.
Publicado: (2013)

Silent Human Trypanosoma brucei gambiense Infections around the Old Gboko Sleeping Sickness Focus in Nigeria
por: Solomon Ngutor, Karshima, et al.
Publicado: (2016)

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes
por: Moreno, S Andrea, et al.
Publicado: (2015)

Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages
por: Vasquez, Juan-José, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_l8mbntnq6ast6qqr515dd5bin3