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Human Rev1 polymerase disrupts G-quadruplex DNA

The Y-family DNA polymerase Rev1 is required for successful replication of G-quadruplex DNA (G4 DNA) in higher eukaryotes. Here we show that human Rev1 (hRev1) disrupts G4 DNA structures and prevents refolding in vitro. Nucleotidyl transfer by hRev1 is not necessary for mechanical unfolding to occur...

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Detalles Bibliográficos
Autores principales:	Eddy, Sarah, Ketkar, Amit, Zafar, Maroof K., Maddukuri, Leena, Choi, Jeong-Yun, Eoff, Robert L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950705/ https://www.ncbi.nlm.nih.gov/pubmed/24366879 http://dx.doi.org/10.1093/nar/gkt1314

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