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Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan

BACKGROUND: Human papilloma virus (HPV) DNA has been detected in breast carcinoma by different laboratorial techniques, suggesting that the virus could play a role in the pathogenesis of this tumor. MATERIALS AND METHODS: It was a descriptive study. Systematic random sampling was used for selecting...

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Autores principales: Manzouri, Leila, Salehi, Rasoul, Shariatpanahi, Shervin, rezaie, Parisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950802/
https://www.ncbi.nlm.nih.gov/pubmed/24627883
http://dx.doi.org/10.4103/2277-9175.125873
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author Manzouri, Leila
Salehi, Rasoul
Shariatpanahi, Shervin
rezaie, Parisa
author_facet Manzouri, Leila
Salehi, Rasoul
Shariatpanahi, Shervin
rezaie, Parisa
author_sort Manzouri, Leila
collection PubMed
description BACKGROUND: Human papilloma virus (HPV) DNA has been detected in breast carcinoma by different laboratorial techniques, suggesting that the virus could play a role in the pathogenesis of this tumor. MATERIALS AND METHODS: It was a descriptive study. Systematic random sampling was used for selecting 55 cases of breast cancer and 51 controls of benign breast lesions from the file of Seyedshohada hospital of Isfahan since 2005-2009. A total of 106 paraffin-embedded specimens were selected and HPV DNA was analyzed by polymerase chain reaction and sequenced for different types of HPV in case of positivity for HPV DNA. Data analysis was performed by SPSS 16 software using descriptive statistic, Chi-square, and Fisher's exact tests. RESULTS: Out of 55 malignant and 51 benign breast specimens, 18.2% (10) and 13.7% (7) were positive to HPV DNA, respectively (P = 0.53); 70% (7) malignant and 43% (3) benign breast specimens were positive to high-risk HPV genotypes. In malignant specimens, the most common high- and low-risk genotypes were HPV-16 (3.6%) and HPV-11 (3.6%), respectively. In benign specimens, the most common high- and low-risk genotypes were HPV-31 (3.9%) and HPV-43 (3.9%), respectively. Among malignant and benign specimens, ductal carcinoma and fibro adenoma were the most common lesions positive to different types of HPV, respectively. CONCLUSION: This study demonstrated the presence of HPV genome in both malignant and benign tumor tissues in women with breast lesions in Isfahan; therefore, further larger epidemiologic studies need to be analyzed to establish the exact role of this virus in the pathogenesis of breast cancer.
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spelling pubmed-39508022014-03-13 Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan Manzouri, Leila Salehi, Rasoul Shariatpanahi, Shervin rezaie, Parisa Adv Biomed Res Original Article BACKGROUND: Human papilloma virus (HPV) DNA has been detected in breast carcinoma by different laboratorial techniques, suggesting that the virus could play a role in the pathogenesis of this tumor. MATERIALS AND METHODS: It was a descriptive study. Systematic random sampling was used for selecting 55 cases of breast cancer and 51 controls of benign breast lesions from the file of Seyedshohada hospital of Isfahan since 2005-2009. A total of 106 paraffin-embedded specimens were selected and HPV DNA was analyzed by polymerase chain reaction and sequenced for different types of HPV in case of positivity for HPV DNA. Data analysis was performed by SPSS 16 software using descriptive statistic, Chi-square, and Fisher's exact tests. RESULTS: Out of 55 malignant and 51 benign breast specimens, 18.2% (10) and 13.7% (7) were positive to HPV DNA, respectively (P = 0.53); 70% (7) malignant and 43% (3) benign breast specimens were positive to high-risk HPV genotypes. In malignant specimens, the most common high- and low-risk genotypes were HPV-16 (3.6%) and HPV-11 (3.6%), respectively. In benign specimens, the most common high- and low-risk genotypes were HPV-31 (3.9%) and HPV-43 (3.9%), respectively. Among malignant and benign specimens, ductal carcinoma and fibro adenoma were the most common lesions positive to different types of HPV, respectively. CONCLUSION: This study demonstrated the presence of HPV genome in both malignant and benign tumor tissues in women with breast lesions in Isfahan; therefore, further larger epidemiologic studies need to be analyzed to establish the exact role of this virus in the pathogenesis of breast cancer. Medknow Publications & Media Pvt Ltd 2014-01-27 /pmc/articles/PMC3950802/ /pubmed/24627883 http://dx.doi.org/10.4103/2277-9175.125873 Text en Copyright: © 2014 Manzouri. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Manzouri, Leila
Salehi, Rasoul
Shariatpanahi, Shervin
rezaie, Parisa
Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan
title Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan
title_full Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan
title_fullStr Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan
title_full_unstemmed Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan
title_short Prevalence of human papilloma virus among women with breast cancer since 2005-2009 in Isfahan
title_sort prevalence of human papilloma virus among women with breast cancer since 2005-2009 in isfahan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950802/
https://www.ncbi.nlm.nih.gov/pubmed/24627883
http://dx.doi.org/10.4103/2277-9175.125873
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