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Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil

In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Se...

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Autores principales: Lara-Silva, Fabiana de Oliveira, Barata, Ricardo Andrade, Michalsky, Érika Monteiro, Ferreira, Eduardo de Castro, Lopes, Maria Olímpia Garcia, Pinheiro, Aimara da Costa, Fortes-Dias, Consuelo Latorre, Dias, Edelberto Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950829/
https://www.ncbi.nlm.nih.gov/pubmed/24707492
http://dx.doi.org/10.1155/2014/592986
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author Lara-Silva, Fabiana de Oliveira
Barata, Ricardo Andrade
Michalsky, Érika Monteiro
Ferreira, Eduardo de Castro
Lopes, Maria Olímpia Garcia
Pinheiro, Aimara da Costa
Fortes-Dias, Consuelo Latorre
Dias, Edelberto Santos
author_facet Lara-Silva, Fabiana de Oliveira
Barata, Ricardo Andrade
Michalsky, Érika Monteiro
Ferreira, Eduardo de Castro
Lopes, Maria Olímpia Garcia
Pinheiro, Aimara da Costa
Fortes-Dias, Consuelo Latorre
Dias, Edelberto Santos
author_sort Lara-Silva, Fabiana de Oliveira
collection PubMed
description In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares.
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spelling pubmed-39508292014-04-06 Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil Lara-Silva, Fabiana de Oliveira Barata, Ricardo Andrade Michalsky, Érika Monteiro Ferreira, Eduardo de Castro Lopes, Maria Olímpia Garcia Pinheiro, Aimara da Costa Fortes-Dias, Consuelo Latorre Dias, Edelberto Santos Biomed Res Int Research Article In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares. Hindawi Publishing Corporation 2014 2014-02-23 /pmc/articles/PMC3950829/ /pubmed/24707492 http://dx.doi.org/10.1155/2014/592986 Text en Copyright © 2014 Fabiana de Oliveira Lara-Silva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lara-Silva, Fabiana de Oliveira
Barata, Ricardo Andrade
Michalsky, Érika Monteiro
Ferreira, Eduardo de Castro
Lopes, Maria Olímpia Garcia
Pinheiro, Aimara da Costa
Fortes-Dias, Consuelo Latorre
Dias, Edelberto Santos
Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil
title Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil
title_full Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil
title_fullStr Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil
title_full_unstemmed Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil
title_short Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil
title_sort rattus norvegicus (rodentia: muridae) infected by leishmania (leishmania) infantum (syn. le. chagasi) in brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950829/
https://www.ncbi.nlm.nih.gov/pubmed/24707492
http://dx.doi.org/10.1155/2014/592986
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