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The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients

BACKGROUND: Ventilator associated pneumonia (VAP) are one of the most common nosocomial infections in intensive care unit (ICU). The ICU patients are at risk of stress ulcer and gastrointestinal bleeding for different reasons. In order to prevent this complication, anti acids are used for patients....

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Autores principales: Khorvash, Farzin, Abbasi, Saeed, Meidani, Mohsen, Dehdashti, Fatemeh, Ataei, Behrooz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950838/
https://www.ncbi.nlm.nih.gov/pubmed/24627860
http://dx.doi.org/10.4103/2277-9175.125789
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author Khorvash, Farzin
Abbasi, Saeed
Meidani, Mohsen
Dehdashti, Fatemeh
Ataei, Behrooz
author_facet Khorvash, Farzin
Abbasi, Saeed
Meidani, Mohsen
Dehdashti, Fatemeh
Ataei, Behrooz
author_sort Khorvash, Farzin
collection PubMed
description BACKGROUND: Ventilator associated pneumonia (VAP) are one of the most common nosocomial infections in intensive care unit (ICU). The ICU patients are at risk of stress ulcer and gastrointestinal bleeding for different reasons. In order to prevent this complication, anti acids are used for patients. This study compared pantoprazole with sucralfate in incidence of ventilator associated pneumonia. MATERIALS AND METHODS: This randomized clinical trial was carried out on ICU patients with mechanical ventilation in Alzahra university hospital in Isfahan from 2010 to 2011. One hundred forty eight ventilated patients were randomly allocated in two groups. The first group was treated with sucralfate and the second group was treated with pantoprazole for stress ulcer prophylaxis and followed up during hospitalization in ICU for nosocomial pneumonia. Data analyzed by SPSS software. RESULTS: One hundred thirty seven patients were selected for study. During the study period, 34 cases (24.8%) acquired pneumonia, of which 10 were in the sucralfate group and 24 were in the pantoprazole group (14.1% vs. 36.4%). According to Chi-square test, rate of pneumonia was significantly lower in patients receiving sucralfate than the pantoprazole group (P < 0.001). CONCLUSION: On the basis of the results, there is a significant relationship between the kind of drug used for stress ulcer and ventilator associated pneumonia. According to this article, rate of pneumonia was significantly lower in patients receiving sucralfate than the pantoprazole group.
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spelling pubmed-39508382014-03-13 The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients Khorvash, Farzin Abbasi, Saeed Meidani, Mohsen Dehdashti, Fatemeh Ataei, Behrooz Adv Biomed Res Original Article BACKGROUND: Ventilator associated pneumonia (VAP) are one of the most common nosocomial infections in intensive care unit (ICU). The ICU patients are at risk of stress ulcer and gastrointestinal bleeding for different reasons. In order to prevent this complication, anti acids are used for patients. This study compared pantoprazole with sucralfate in incidence of ventilator associated pneumonia. MATERIALS AND METHODS: This randomized clinical trial was carried out on ICU patients with mechanical ventilation in Alzahra university hospital in Isfahan from 2010 to 2011. One hundred forty eight ventilated patients were randomly allocated in two groups. The first group was treated with sucralfate and the second group was treated with pantoprazole for stress ulcer prophylaxis and followed up during hospitalization in ICU for nosocomial pneumonia. Data analyzed by SPSS software. RESULTS: One hundred thirty seven patients were selected for study. During the study period, 34 cases (24.8%) acquired pneumonia, of which 10 were in the sucralfate group and 24 were in the pantoprazole group (14.1% vs. 36.4%). According to Chi-square test, rate of pneumonia was significantly lower in patients receiving sucralfate than the pantoprazole group (P < 0.001). CONCLUSION: On the basis of the results, there is a significant relationship between the kind of drug used for stress ulcer and ventilator associated pneumonia. According to this article, rate of pneumonia was significantly lower in patients receiving sucralfate than the pantoprazole group. Medknow Publications & Media Pvt Ltd 2014-01-27 /pmc/articles/PMC3950838/ /pubmed/24627860 http://dx.doi.org/10.4103/2277-9175.125789 Text en Copyright: © 2014 Khorvash. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Khorvash, Farzin
Abbasi, Saeed
Meidani, Mohsen
Dehdashti, Fatemeh
Ataei, Behrooz
The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients
title The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients
title_full The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients
title_fullStr The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients
title_full_unstemmed The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients
title_short The comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients
title_sort comparison between proton pump inhibitors and sucralfate in incidence of ventilator associated pneumonia in critically ill patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950838/
https://www.ncbi.nlm.nih.gov/pubmed/24627860
http://dx.doi.org/10.4103/2277-9175.125789
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