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Glyco-engineered anti-EGFR mAb elicits ADCC by NK cells from colorectal cancer patients irrespective of chemotherapy

BACKGROUND: The epidermal growth factor receptor (EGFR) is overexpressed in colorectal cancer (CRC), and is correlated with poor prognosis, making it an attractive target for monoclonal antibody (mAb) therapy. A component of the therapeutic efficacy of IgG1 mAbs is their stimulation of antibody-depe...

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Detalles Bibliográficos
Autores principales:	Oppenheim, D E, Spreafico, R, Etuk, A, Malone, D, Amofah, E, Peña-Murillo, C, Murray, T, McLaughlin, L, Choi, B S, Allan, S, Belousov, A, Passioukov, A, Gerdes, C, Umaña, P, Farzaneh, F, Ross, P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950873/ https://www.ncbi.nlm.nih.gov/pubmed/24496456 http://dx.doi.org/10.1038/bjc.2014.35

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