Effect of oral anticoagulants on the outcome of faecal immunochemical test

BACKGROUND: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. METHODS: Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75 ng ml(–1)) between November 2008 and June...

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Detalles Bibliográficos
Autores principales: Bujanda, L, Sarasqueta, C, Lanas, Á, Quintero, E, Cubiella, J, Hernandez, V, Morillas, J D, Perez-Fernández, T, Salas, D, Andreu, M, Carballo, F, Bessa, X, Portillo, I, Jover, R, Balaguer, F, Cosme, A, Castells, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950875/
https://www.ncbi.nlm.nih.gov/pubmed/24496455
http://dx.doi.org/10.1038/bjc.2014.38
Descripción
Sumario:BACKGROUND: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. METHODS: Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75 ng ml(–1)) between November 2008 and June 2011. RESULTS: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3–1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4–10.8; P=0.4). CONCLUSIONS: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

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