Cargando…

Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

BACKGROUND: Glioblastoma multiforme (GBM), a highly invasive primary brain tumour, remains an incurable disease. Rho GTPases and their activators, guanine nucleotide exchange factors (GEFs), have central roles in GBM invasion. Anti-angiogenic therapies may stimulate GBM invasion via HGF/c-Met signal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murray, D W, Didier, S, Chan, A, Paulino, V, Van Aelst, L, Ruggieri, R, Tran, N L, Byrne, A T, Symons, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950876/ https://www.ncbi.nlm.nih.gov/pubmed/24518591 http://dx.doi.org/10.1038/bjc.2014.39

Ejemplares similares

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma
por: Lavictoire, Sylvie J., et al.
Publicado: (2021)

Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets
por: Aslan, Joseph E, et al.
Publicado: (2011)

Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors
por: Marei, Hadir, et al.
Publicado: (2016)

Structural biology of DOCK‐family guanine nucleotide exchange factors
por: Boland, Andreas, et al.
Publicado: (2022)

Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
por: Arthur, William T., et al.
Publicado: (2004)

Zizimin and Dock guanine nucleotide exchange factors in cell function and disease
por: Pakes, Nicholl K., et al.
Publicado: (2013)

Insights into the biological functions of Dock family guanine nucleotide exchange factors
por: Laurin, Mélanie, et al.
Publicado: (2014)

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
por: Marei, Hadir, et al.
Publicado: (2016)

MET phosphorylation predicts poor outcome in small cell lung carcinoma and its inhibition blocks HGF-induced effects in MET mutant cell lines
por: Arriola, E, et al.
Publicado: (2011)

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule
por: Ferrandez, Yann, et al.
Publicado: (2017)

Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells
por: Bhat, H F, et al.
Publicado: (2014)

Interleukin-6 gene amplification and shortened survival in glioblastoma patients
por: Tchirkov, A, et al.
Publicado: (2007)

A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling
por: Yokdang, N, et al.
Publicado: (2011)

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho
por: van Leeuwen, Frank N., et al.
Publicado: (1997)

Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma
por: Spiegl-Kreinecker, S, et al.
Publicado: (2007)

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation
por: van Rijssel, Jos, et al.
Publicado: (2012)

Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma
por: Xie, D, et al.
Publicado: (2006)

Development of robust discriminant equations for assessing subtypes of glioblastoma biopsies
por: Castells, X, et al.
Publicado: (2012)

Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1–PI3K–Rac1 pathway
por: Kamura, S, et al.
Publicado: (2010)

P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina
por: Sherry, David M, et al.
Publicado: (2013)

Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation
por: Kang, In Soon, et al.
Publicado: (2020)

Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib
por: Beuselinck, B, et al.
Publicado: (2013)

The many faces of the guanine-nucleotide exchange factor trio
por: van Rijssel, Jos, et al.
Publicado: (2012)

Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma
por: Shen, J, et al.
Publicado: (2013)

MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways
por: Wu, N, et al.
Publicado: (2013)

Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer
por: Kim, J C, et al.
Publicado: (2013)

Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy
por: Dunn, J, et al.
Publicado: (2009)

CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells
por: Maciaczyk, D, et al.
Publicado: (2017)

Two isoforms of the RAC-specific guanine nucleotide exchange factor TIAM2 act oppositely on transmission ratio distortion by the mouse t-haplotype
por: Charron, Yves, et al.
Publicado: (2019)

BuGZ exhibits guanine nucleotide exchange factor activity toward tubulin
por: Yon, Wesley J., et al.
Publicado: (2023)

The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells
por: Huang, J, et al.
Publicado: (2010)

HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma
por: Thuring, Camilla, et al.
Publicado: (2015)

Trapp Stimulates Guanine Nucleotide Exchange on Ypt1p
por: Wang, Wei, et al.
Publicado: (2000)

Scambio, a novel guanine nucleotide exchange factor for Rho
por: Curtis, Christina, et al.
Publicado: (2004)

The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin
por: Ahmad, K. Farid, et al.
Publicado: (2010)

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes
por: Randazzo, Paul A, et al.
Publicado: (2014)

Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies
por: Iqbal, U, et al.
Publicado: (2010)

The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain
por: Hong, Jaewoo, et al.
Publicado: (2020)

Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma
por: Dong, Zhen, et al.
Publicado: (2017)

Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer
por: Doherty, G A, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_usdesut4b31lknars6vfoq5o5r