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Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
BACKGROUND: Metastatic breast cancer is a severe condition without curative treatment. How relative and absolute risk of distant metastasis varies over time since diagnosis, as a function of treatment, age and tumour characteristics, has not been studied in detail. METHODS: A total of 9514 women und...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950882/ https://www.ncbi.nlm.nih.gov/pubmed/24434426 http://dx.doi.org/10.1038/bjc.2014.5 |
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author | Colzani, E Johansson, A L V Liljegren, A Foukakis, T Clements, M Adolfsson, J Hall, P Czene, K |
author_facet | Colzani, E Johansson, A L V Liljegren, A Foukakis, T Clements, M Adolfsson, J Hall, P Czene, K |
author_sort | Colzani, E |
collection | PubMed |
description | BACKGROUND: Metastatic breast cancer is a severe condition without curative treatment. How relative and absolute risk of distant metastasis varies over time since diagnosis, as a function of treatment, age and tumour characteristics, has not been studied in detail. METHODS: A total of 9514 women under the age of 75 when diagnosed with breast cancer in Stockholm and Gotland regions during 1990–2006 were followed up for metastasis (mean follow-up=5.7 years). Time-dependent development of distant metastasis was analysed using flexible parametric survival models and presented as hazard ratio (HR) and cumulative risk. RESULTS: A total of 995 (10.4%) patients developed distant metastasis; the most common sites were skeleton (32.5%) and multiple sites (28.3%). Women younger than 50 years at diagnosis, with lymph node-positive, oestrogen receptor (ER)-negative, >20 mm tumours and treated only locally, had the highest risk of distant metastasis (0–5 years' cumulative risk =0.55; 95% confidence interval (CI): 0.47–0.64). Women older than 50 years at diagnosis, with ER-positive, lymph node-negative and ⩽20-mm tumours, had the same and lowest cumulative risk of developing metastasis 0–5 and 5–10 years (cumulative risk=0.03; 95% CI: 0.02–0.04). In the period of 5–10 years after diagnosis, women with ER-positive, lymph node-positive and >20-mm tumours were at highest risk of distant recurrence. Women with ER-negative tumours showed a decline in risk during this period. CONCLUSION: Our data show no support for discontinuation at 5 years of clinical follow-up in breast cancer patients and suggest further investigation on differential clinical follow-up for different subgroups of patients. |
format | Online Article Text |
id | pubmed-3950882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-39508822015-03-04 Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics Colzani, E Johansson, A L V Liljegren, A Foukakis, T Clements, M Adolfsson, J Hall, P Czene, K Br J Cancer Epidemiology BACKGROUND: Metastatic breast cancer is a severe condition without curative treatment. How relative and absolute risk of distant metastasis varies over time since diagnosis, as a function of treatment, age and tumour characteristics, has not been studied in detail. METHODS: A total of 9514 women under the age of 75 when diagnosed with breast cancer in Stockholm and Gotland regions during 1990–2006 were followed up for metastasis (mean follow-up=5.7 years). Time-dependent development of distant metastasis was analysed using flexible parametric survival models and presented as hazard ratio (HR) and cumulative risk. RESULTS: A total of 995 (10.4%) patients developed distant metastasis; the most common sites were skeleton (32.5%) and multiple sites (28.3%). Women younger than 50 years at diagnosis, with lymph node-positive, oestrogen receptor (ER)-negative, >20 mm tumours and treated only locally, had the highest risk of distant metastasis (0–5 years' cumulative risk =0.55; 95% confidence interval (CI): 0.47–0.64). Women older than 50 years at diagnosis, with ER-positive, lymph node-negative and ⩽20-mm tumours, had the same and lowest cumulative risk of developing metastasis 0–5 and 5–10 years (cumulative risk=0.03; 95% CI: 0.02–0.04). In the period of 5–10 years after diagnosis, women with ER-positive, lymph node-positive and >20-mm tumours were at highest risk of distant recurrence. Women with ER-negative tumours showed a decline in risk during this period. CONCLUSION: Our data show no support for discontinuation at 5 years of clinical follow-up in breast cancer patients and suggest further investigation on differential clinical follow-up for different subgroups of patients. Nature Publishing Group 2014-03-04 2014-01-16 /pmc/articles/PMC3950882/ /pubmed/24434426 http://dx.doi.org/10.1038/bjc.2014.5 Text en Copyright © 2014 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Epidemiology Colzani, E Johansson, A L V Liljegren, A Foukakis, T Clements, M Adolfsson, J Hall, P Czene, K Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics |
title | Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics |
title_full | Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics |
title_fullStr | Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics |
title_full_unstemmed | Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics |
title_short | Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics |
title_sort | time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950882/ https://www.ncbi.nlm.nih.gov/pubmed/24434426 http://dx.doi.org/10.1038/bjc.2014.5 |
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