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Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics

BACKGROUND: Metastatic breast cancer is a severe condition without curative treatment. How relative and absolute risk of distant metastasis varies over time since diagnosis, as a function of treatment, age and tumour characteristics, has not been studied in detail. METHODS: A total of 9514 women und...

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Autores principales: Colzani, E, Johansson, A L V, Liljegren, A, Foukakis, T, Clements, M, Adolfsson, J, Hall, P, Czene, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950882/
https://www.ncbi.nlm.nih.gov/pubmed/24434426
http://dx.doi.org/10.1038/bjc.2014.5
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author Colzani, E
Johansson, A L V
Liljegren, A
Foukakis, T
Clements, M
Adolfsson, J
Hall, P
Czene, K
author_facet Colzani, E
Johansson, A L V
Liljegren, A
Foukakis, T
Clements, M
Adolfsson, J
Hall, P
Czene, K
author_sort Colzani, E
collection PubMed
description BACKGROUND: Metastatic breast cancer is a severe condition without curative treatment. How relative and absolute risk of distant metastasis varies over time since diagnosis, as a function of treatment, age and tumour characteristics, has not been studied in detail. METHODS: A total of 9514 women under the age of 75 when diagnosed with breast cancer in Stockholm and Gotland regions during 1990–2006 were followed up for metastasis (mean follow-up=5.7 years). Time-dependent development of distant metastasis was analysed using flexible parametric survival models and presented as hazard ratio (HR) and cumulative risk. RESULTS: A total of 995 (10.4%) patients developed distant metastasis; the most common sites were skeleton (32.5%) and multiple sites (28.3%). Women younger than 50 years at diagnosis, with lymph node-positive, oestrogen receptor (ER)-negative, >20 mm tumours and treated only locally, had the highest risk of distant metastasis (0–5 years' cumulative risk =0.55; 95% confidence interval (CI): 0.47–0.64). Women older than 50 years at diagnosis, with ER-positive, lymph node-negative and ⩽20-mm tumours, had the same and lowest cumulative risk of developing metastasis 0–5 and 5–10 years (cumulative risk=0.03; 95% CI: 0.02–0.04). In the period of 5–10 years after diagnosis, women with ER-positive, lymph node-positive and >20-mm tumours were at highest risk of distant recurrence. Women with ER-negative tumours showed a decline in risk during this period. CONCLUSION: Our data show no support for discontinuation at 5 years of clinical follow-up in breast cancer patients and suggest further investigation on differential clinical follow-up for different subgroups of patients.
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spelling pubmed-39508822015-03-04 Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics Colzani, E Johansson, A L V Liljegren, A Foukakis, T Clements, M Adolfsson, J Hall, P Czene, K Br J Cancer Epidemiology BACKGROUND: Metastatic breast cancer is a severe condition without curative treatment. How relative and absolute risk of distant metastasis varies over time since diagnosis, as a function of treatment, age and tumour characteristics, has not been studied in detail. METHODS: A total of 9514 women under the age of 75 when diagnosed with breast cancer in Stockholm and Gotland regions during 1990–2006 were followed up for metastasis (mean follow-up=5.7 years). Time-dependent development of distant metastasis was analysed using flexible parametric survival models and presented as hazard ratio (HR) and cumulative risk. RESULTS: A total of 995 (10.4%) patients developed distant metastasis; the most common sites were skeleton (32.5%) and multiple sites (28.3%). Women younger than 50 years at diagnosis, with lymph node-positive, oestrogen receptor (ER)-negative, >20 mm tumours and treated only locally, had the highest risk of distant metastasis (0–5 years' cumulative risk =0.55; 95% confidence interval (CI): 0.47–0.64). Women older than 50 years at diagnosis, with ER-positive, lymph node-negative and ⩽20-mm tumours, had the same and lowest cumulative risk of developing metastasis 0–5 and 5–10 years (cumulative risk=0.03; 95% CI: 0.02–0.04). In the period of 5–10 years after diagnosis, women with ER-positive, lymph node-positive and >20-mm tumours were at highest risk of distant recurrence. Women with ER-negative tumours showed a decline in risk during this period. CONCLUSION: Our data show no support for discontinuation at 5 years of clinical follow-up in breast cancer patients and suggest further investigation on differential clinical follow-up for different subgroups of patients. Nature Publishing Group 2014-03-04 2014-01-16 /pmc/articles/PMC3950882/ /pubmed/24434426 http://dx.doi.org/10.1038/bjc.2014.5 Text en Copyright © 2014 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Colzani, E
Johansson, A L V
Liljegren, A
Foukakis, T
Clements, M
Adolfsson, J
Hall, P
Czene, K
Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
title Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
title_full Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
title_fullStr Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
title_full_unstemmed Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
title_short Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
title_sort time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950882/
https://www.ncbi.nlm.nih.gov/pubmed/24434426
http://dx.doi.org/10.1038/bjc.2014.5
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