Cargando…

Trichostatin A Suppresses EGFR Expression through Induction of MicroRNA-7 in an HDAC-Independent Manner in Lapatinib-Treated Cells

Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to improve the survival rate of patients with advanced HER2-positive breast cancers. However, the off-target activity of lapatinib in inducing EGFR expression without tyrosine kinase activity was demonstrated to render HER2-negati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tu, Chih-Yen, Chen, Chia-Hung, Hsia, Te-Chun, Hsu, Min-Hsiang, Wei, Ya-Ling, Yu, Meng-Chieh, Chen, Wen-Shu, Hsu, Ke-Wei, Yeh, Ming-Hsin, Liu, Liang-Chih, Chen, Yun-Ju, Huang, Wei-Chien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950925/ https://www.ncbi.nlm.nih.gov/pubmed/24707474 http://dx.doi.org/10.1155/2014/168949

Ejemplares similares

Lapatinib–induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors
por: Chen, Yun-Ju, et al.
Publicado: (2013)

A real-world study comparing perioperative chemotherapy and EGFR-tyrosine kinase inhibitors for treatment of resected stage III EGFR-mutant adenocarcinoma
por: Chen, Chieh-Lung, et al.
Publicado: (2023)

The Impact of Acquired EGFR T790M Mutation and EGFR Circulating Cell-Free DNA on Survival in Patients with Lung Adenocarcinoma Following EGFR-TKI Therapy
por: Cheng, Wen-Chien, et al.
Publicado: (2021)

Bevacizumab versus Ramucirumab in EGFR-Mutated Metastatic Non-Small-Cell Lung Cancer Patients: A Real-World Observational Study
por: Cheng, Wen-Chien, et al.
Publicado: (2023)

When to add anti-angiogenesis drugs to EGFR-mutated metastatic non–small cell lung cancer patients: a real-world study from Taiwan
por: Chen, Chieh-Lung, et al.
Publicado: (2022)

The Feasibility of Interventional Pulmonology Methods for Detecting the T790M Mutation after the First or Second-Generation EGFR-TKI Resistance of Non-Small Cell Lung Cancer
por: Cheng, Wen-Chien, et al.
Publicado: (2022)

miR‐221 confers lapatinib resistance by negatively regulating p27(kip1) in HER2‐positive breast cancer
por: Huynh, Thanh Kieu, et al.
Publicado: (2021)

Cigarette smoke enhances oncogene addiction to c‐MET and desensitizes EGFR‐expressing non‐small cell lung cancer to EGFR TKIs
por: Tu, Chih‐Yen, et al.
Publicado: (2018)

PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs
por: Chen, Chia-Hung, et al.
Publicado: (2021)

Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC
por: Cheng, Fang-Ju, et al.
Publicado: (2020)

The impact of rescue or maintenance therapy with EGFR TKIs for Stage IIIb-IV non-squamous non-small-cell lung cancer patients requiring mechanical ventilation
por: Hsia, Te-Chun, et al.
Publicado: (2014)

Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6
por: Hsiao, Yu-Chun, et al.
Publicado: (2015)

Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A
por: Gialitakis, Manolis, et al.
Publicado: (2006)

Endobronchial Ultrasound Changed the World of Lung Cancer Patients: A 11-Year Institutional Experience
por: Chen, Chia-Hung, et al.
Publicado: (2015)

Interventional pulmonology for patients with central airway obstruction: An 8-year institutional experience
por: Chen, Chia-Hung, et al.
Publicado: (2017)

When to Use Initial Triple Therapy in COPD: Adding a LAMA to ICS/LABA by Clinically Important Deterioration Assessment
por: Cheng, Wen-Chien, et al.
Publicado: (2020)

Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide
por: Chang, J, et al.
Publicado: (2012)

HDAC Inhibition Decreases the Expression of EGFR in Colorectal Cancer Cells
por: Chou, Chia-Wei, et al.
Publicado: (2011)

MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701
por: Chen, Chia‐Hung, et al.
Publicado: (2017)

Risk of Pleural Empyema in Adult Patients With Asthma: A Nationwide Retrospective Cohort Study
por: Liao, Wei-Chih, et al.
Publicado: (2022)

Risk of Chronic Kidney Disease in Pneumoconiosis: Results from a Retrospective Cohort Study (2008–2019)
por: Wei, Chao-Hsuan, et al.
Publicado: (2023)

EGFR Tyrosine Kinase Inhibitor–Associated Interstitial Lung Disease During the Coronavirus Disease 2019 Pandemic
por: Chang, Hsu-Liang, et al.
Publicado: (2020)

HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes
por: Lv, Xin, et al.
Publicado: (2021)

The NPR1 ortholog PhaNPR1 is required for the induction of PhaPR1 in Phalaenopsis aphrodite
por: Chen, Jen-Chih, et al.
Publicado: (2013)

Prognostic Value of Tumor Size in Resected Stage IIIA-N2 Non-Small-Cell Lung Cancer
por: Chen, Chih-Yu, et al.
Publicado: (2020)

Increased Risk of Tuberculosis in Patients With Type 1 Diabetes Mellitus: Results From a Population-Based Cohort Study in Taiwan
por: Shen, Te-Chun, et al.
Publicado: (2014)

HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3
por: Chen, Jhen-Yu, et al.
Publicado: (2015)

Comparison of the effects of the three major tyrosine kinase inhibitors as first-line therapy for non-small-cell lung cancer harboring epidermal growth factor receptor mutations
por: Tu, Chih-Yen, et al.
Publicado: (2018)

The optimal therapy strategy for epidermal growth factor receptor‐mutated non‐small cell lung cancer patients with brain metastasis: A real‐world study from Taiwan
por: Cheng, Wen‐Chien, et al.
Publicado: (2022)

Efficacy of Prophylactic Traditional Chinese Medicine on Skin Toxicity of Afatinib in EGFR Mutation-Positive Advanced Lung Adenocarcinoma: A Single-Center, Prospective, Double-Blinded, Randomized-Controlled Pilot Trial
por: Li, Chia-Ling, et al.
Publicado: (2022)

Histological Transformation after Acquired Resistance to the Third-Generation EGFR-TKI in Patients with Advanced EGFR-Mutant Lung Adenocarcinoma
por: Lee, Po-Hsin, et al.
Publicado: (2022)

Pin1 coordinates HDAC6 upregulation with cell migration in lung cancer cells
por: Chuang, Hsiang-Hao, et al.
Publicado: (2020)

Influence of the Timing of Leptomeningeal Metastasis on the Outcome of EGFR-Mutant Lung Adenocarcinoma Patients and Predictors of Detectable EGFR Mutations in Cerebrospinal Fluid
por: Liao, Pei-Ya, et al.
Publicado: (2022)

Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer
por: Wei, Tzu-Tang, et al.
Publicado: (2015)

Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia
por: Chen, Yu-Jen, et al.
Publicado: (2016)

In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis
por: Li, Ling, et al.
Publicado: (2016)

Amiodarone Use Is Associated With Increased Risk of Stroke in Patients With Nonvalvular Atrial Fibrillation: A Nationwide Population-Based Cohort Study
por: Chen, Wei-Chun, et al.
Publicado: (2015)

Acetabular Revision Surgery with Tantalum Trabecular Metal Acetabular Cup for Failed Acetabular Cage Reconstruction with Bone Allografts: A Retrospective Study with Mid- to Long-Term Follow-Up
por: Hsu, Chen-Heng, et al.
Publicado: (2022)

Inhibition of Protein Phosphatase 1 Stimulates Noncanonical ER Stress eIF2α Activation to Enhance Fisetin-induced Chemosensitivity in HDAC Inhibitor-resistant Hepatocellular Carcinoma Cells
por: Liu, Yi-Sheng, et al.
Publicado: (2019)

Lapatinib Induces Autophagy, Apoptosis and Megakaryocytic Differentiation in Chronic Myelogenous Leukemia K562 Cells
por: Huang, Huey-Lan, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2sqfrkuivjmggsuqp2a3pmiqp8