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Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo

MN (motor neuron) death in amyotrophic lateral sclerosis may be mediated by glutamatergic excitotoxicity. Previously, our group showed that the microdialysis perfusion of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) in the rat lumbar spinal cord induced MN death and permanent paralysis w...

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Detalles Bibliográficos
Autores principales:	Santa-Cruz, Luz Diana, Tapia, Ricardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Neurochemistry 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950966/ https://www.ncbi.nlm.nih.gov/pubmed/24524836 http://dx.doi.org/10.1042/AN20130046

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