Cargando…

Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo

MN (motor neuron) death in amyotrophic lateral sclerosis may be mediated by glutamatergic excitotoxicity. Previously, our group showed that the microdialysis perfusion of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) in the rat lumbar spinal cord induced MN death and permanent paralysis w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santa-Cruz, Luz Diana, Tapia, Ricardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Neurochemistry 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950966/ https://www.ncbi.nlm.nih.gov/pubmed/24524836 http://dx.doi.org/10.1042/AN20130046

Ejemplares similares

Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates
por: Netzahualcoyotzi, Citlalli, et al.
Publicado: (2015)

Sodium butyrate does not protect spinal motor neurons from AMPA-induced excitotoxic degeneration in vivo
por: Prior-González, Mara, et al.
Publicado: (2023)

Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism
por: Lazo-Gomez, Rafael, et al.
Publicado: (2017)

Tetanus toxin C-fragment protects against excitotoxic spinal motoneuron degeneration in vivo
por: Netzahualcoyotzi, Citlalli, et al.
Publicado: (2018)

Inducing Chronic Excitotoxicity in the Mouse Spinal Cord to Investigate Lower Motor Neuron Degeneration
por: Blizzard, Catherine A., et al.
Publicado: (2016)

Delayed administration of VEGF rescues spinal motor neurons from death with a short effective time frame in excitotoxic experimental models in vivo
por: Tovar-y-Romo, Luis B, et al.
Publicado: (2012)

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
por: Pozniak, Christine D., et al.
Publicado: (2013)

Histone deacetylases and their role in motor neuron degeneration
por: Lazo-Gómez, Rafael, et al.
Publicado: (2013)

Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity
por: Brockington, Alice, et al.
Publicado: (2012)

C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits
por: Koppers, Max, et al.
Publicado: (2015)

Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS
por: Shadrach, Jennifer L., et al.
Publicado: (2021)

Dibutyryl Cyclic Adenosine Monophosphate Rescues the Neurons From Degeneration in Stab Wound and Excitotoxic Injury Models
por: Abd-El-Basset, Ebtesam M., et al.
Publicado: (2018)

NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity
por: Madji Hounoum, Blandine, et al.
Publicado: (2016)

Procyanidin B2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress
por: Sutcliffe, Taylor C., et al.
Publicado: (2017)

Limitations and Challenges in Modeling Diseases Involving Spinal Motor Neuron Degeneration in Vitro
por: Bucchia, Monica, et al.
Publicado: (2018)

Influences of the circadian clock on neuronal susceptibility to excitotoxicity
por: Karmarkar, Sumedha W., et al.
Publicado: (2013)

Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity
por: Wang, Jiejie, et al.
Publicado: (2020)

Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo
por: Formella, Isabel, et al.
Publicado: (2018)

BMP4 Is a Peripherally-Derived Factor for Motor Neurons and Attenuates Glutamate-Induced Excitotoxicity In Vitro
por: Chou, Hui-Ju, et al.
Publicado: (2013)

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity
por: Blizzard, Catherine A., et al.
Publicado: (2015)

Oxidative stress disrupts the cytoskeleton of spinal motor neurons
por: Chen, Jian, et al.
Publicado: (2022)

N-Acetylcysteine Induces Apoptotic, Oxidative and Excitotoxic Neuronal Death in Mouse Cortical Cultures
por: Hwang, Shinae, et al.
Publicado: (2022)

Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca(2+) Signaling in Amyotrophic Lateral Sclerosis
por: Jaiswal, Manoj Kumar
Publicado: (2017)

Dopamine protects neurons against glutamate-induced excitotoxicity
por: Vaarmann, A, et al.
Publicado: (2013)

Differentiation renders susceptibility to excitotoxicity in HT22 neurons☆
por: He, Minchao, et al.
Publicado: (2013)

Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus
por: Lee, Choong Hyun, et al.
Publicado: (2015)

Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
por: Krasil’nikova, Irina, et al.
Publicado: (2019)

Delivering progranulin to neuronal lysosomes protects against excitotoxicity
por: Davis, Skylar E., et al.
Publicado: (2021)

Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity
por: Zgodova, Arina, et al.
Publicado: (2022)

Preventive and Therapeutic Autoantibodies Protect against Neuronal Excitotoxicity
por: Zhou, Xianjin
Publicado: (2023)

Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethality
por: Sargent, Dorian, et al.
Publicado: (2021)

Motor neurons and the generation of spinal motor neuron diversity
por: Stifani, Nicolas
Publicado: (2014)

Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo
por: Chimura, Takahiko, et al.
Publicado: (2015)

Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
por: Pose-Utrilla, Julia, et al.
Publicado: (2017)

Motor Alterations Induced by Chronic 4-Aminopyridine Infusion in the Spinal Cord In vivo: Role of Glutamate and GABA Receptors
por: Lazo-Gómez, Rafael, et al.
Publicado: (2016)

Subacute combined degeneration of the spinal cord masking motor neuron disease: a case report
por: Loveland, Paula, et al.
Publicado: (2019)

The Ethanol Fraction of White Rose Petal Extract Abrogates Excitotoxicity-Induced Neuronal Damage In Vivo and In Vitro through Inhibition of Oxidative Stress and Proinflammation
por: Yon, Jung-Min, et al.
Publicado: (2018)

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
por: Shin, Ji-Yeon, et al.
Publicado: (2005)

HIP/PAP prevents excitotoxic neuronal death and promotes plasticity
por: Haldipur, Parthiv, et al.
Publicado: (2014)

Astrocytes enhance the tolerance of rat cortical neurons to glutamate excitotoxicity
por: Zhang, Li-Nan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tfr6jte5kng3ucci2qs3ch8487