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A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations

A new series of novel triazolothiadiazepinylindole analogues were synthesized with an aim to examine possible antioxidant and antimicrobial activities. The titled compounds (3a–z) were obtained in good yield by reacting 5-(5-substituted-3-phenyl-1H-indol-2-yl)-4-amino-4H-1,2,4-triazole-3-thiols 1a–c...

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Autores principales: Biradar, Jaiprakash Sharanappa, Rajesab, Parveen, Biradar, Naveen Jaiprakash, Somappa, Sasidhar Balappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951047/
https://www.ncbi.nlm.nih.gov/pubmed/24707209
http://dx.doi.org/10.1155/2014/581737
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author Biradar, Jaiprakash Sharanappa
Rajesab, Parveen
Biradar, Naveen Jaiprakash
Somappa, Sasidhar Balappa
author_facet Biradar, Jaiprakash Sharanappa
Rajesab, Parveen
Biradar, Naveen Jaiprakash
Somappa, Sasidhar Balappa
author_sort Biradar, Jaiprakash Sharanappa
collection PubMed
description A new series of novel triazolothiadiazepinylindole analogues were synthesized with an aim to examine possible antioxidant and antimicrobial activities. The titled compounds (3a–z) were obtained in good yield by reacting 5-(5-substituted-3-phenyl-1H-indol-2-yl)-4-amino-4H-1,2,4-triazole-3-thiols 1a–c with 3-(2,5-disubstituted-1H-indol-3-yl)-1(4-substituted phenyl)prop-2-en-1-ones 2a–i. All the newly synthesized compounds were characterized by IR, (1)H NMR, mass spectroscopic and analytical data. The synthesized analogues were tested for antioxidant and antimicrobial potency. Among the tested compounds 3a–c and 3j–l have shown very promising free radical scavenging activity and total antioxidant capacity. Compounds 3d–f, 3m–o, and 3s–z have shown excellent ferric reducing antioxidant activity. An outstanding antimicrobial activity is observed with compounds 3a–c and 3j–l.
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spelling pubmed-39510472014-04-06 A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations Biradar, Jaiprakash Sharanappa Rajesab, Parveen Biradar, Naveen Jaiprakash Somappa, Sasidhar Balappa ScientificWorldJournal Research Article A new series of novel triazolothiadiazepinylindole analogues were synthesized with an aim to examine possible antioxidant and antimicrobial activities. The titled compounds (3a–z) were obtained in good yield by reacting 5-(5-substituted-3-phenyl-1H-indol-2-yl)-4-amino-4H-1,2,4-triazole-3-thiols 1a–c with 3-(2,5-disubstituted-1H-indol-3-yl)-1(4-substituted phenyl)prop-2-en-1-ones 2a–i. All the newly synthesized compounds were characterized by IR, (1)H NMR, mass spectroscopic and analytical data. The synthesized analogues were tested for antioxidant and antimicrobial potency. Among the tested compounds 3a–c and 3j–l have shown very promising free radical scavenging activity and total antioxidant capacity. Compounds 3d–f, 3m–o, and 3s–z have shown excellent ferric reducing antioxidant activity. An outstanding antimicrobial activity is observed with compounds 3a–c and 3j–l. Hindawi Publishing Corporation 2014-02-20 /pmc/articles/PMC3951047/ /pubmed/24707209 http://dx.doi.org/10.1155/2014/581737 Text en Copyright © 2014 Jaiprakash Sharanappa Biradar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Biradar, Jaiprakash Sharanappa
Rajesab, Parveen
Biradar, Naveen Jaiprakash
Somappa, Sasidhar Balappa
A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations
title A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations
title_full A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations
title_fullStr A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations
title_full_unstemmed A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations
title_short A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations
title_sort mini library of novel triazolothiadiazepinylindole analogues: synthesis, antioxidant and antimicrobial evaluations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951047/
https://www.ncbi.nlm.nih.gov/pubmed/24707209
http://dx.doi.org/10.1155/2014/581737
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