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Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival
MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the significance and prognostic value of miR-630...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951214/ https://www.ncbi.nlm.nih.gov/pubmed/24621930 http://dx.doi.org/10.1371/journal.pone.0090526 |
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author | Chu, Dake Zhao, Zhengwei Li, Yunming Li, Jipeng Zheng, Jianyong Wang, Weizhong Zhao, Qingchuan Ji, Gang |
author_facet | Chu, Dake Zhao, Zhengwei Li, Yunming Li, Jipeng Zheng, Jianyong Wang, Weizhong Zhao, Qingchuan Ji, Gang |
author_sort | Chu, Dake |
collection | PubMed |
description | MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the significance and prognostic value of miR-630 in human gastric cancer. Gastric cancer and adjacent normal specimens from 236 patients from who had not received neoadjuvant chemotherapy were collected. The expression of miR-630 was investigated by quantitative real-time PCR assay and its association with overall survival of patients was analyzed by statistical analysis. MiR-630 expression level was significantly elevated in gastric cancer in comparison to adjacent normal specimens. It is also proved that miR-630 expression was to be associated with gastric cancer invasion, lymph node metastasis, distant metastasis and TNM stage. In addition, survival analysis proved that elevated miR-630 expression was associated with poor overall survival of patients. Multivariate survival analysis also proved that miR-630 was an independent prognostic marker after adjusted for known prognostic factors. The present study proved the over-expression of miR-630 and its association with tumor progression in human gastric cancer. It also provided the first evidence that miR-630 expression was an independent prognostic factor for patients with gastric cancer, which might be a potential valuable biomarker for gastric cancer. |
format | Online Article Text |
id | pubmed-3951214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39512142014-03-13 Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival Chu, Dake Zhao, Zhengwei Li, Yunming Li, Jipeng Zheng, Jianyong Wang, Weizhong Zhao, Qingchuan Ji, Gang PLoS One Research Article MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the significance and prognostic value of miR-630 in human gastric cancer. Gastric cancer and adjacent normal specimens from 236 patients from who had not received neoadjuvant chemotherapy were collected. The expression of miR-630 was investigated by quantitative real-time PCR assay and its association with overall survival of patients was analyzed by statistical analysis. MiR-630 expression level was significantly elevated in gastric cancer in comparison to adjacent normal specimens. It is also proved that miR-630 expression was to be associated with gastric cancer invasion, lymph node metastasis, distant metastasis and TNM stage. In addition, survival analysis proved that elevated miR-630 expression was associated with poor overall survival of patients. Multivariate survival analysis also proved that miR-630 was an independent prognostic marker after adjusted for known prognostic factors. The present study proved the over-expression of miR-630 and its association with tumor progression in human gastric cancer. It also provided the first evidence that miR-630 expression was an independent prognostic factor for patients with gastric cancer, which might be a potential valuable biomarker for gastric cancer. Public Library of Science 2014-03-12 /pmc/articles/PMC3951214/ /pubmed/24621930 http://dx.doi.org/10.1371/journal.pone.0090526 Text en © 2014 Chu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chu, Dake Zhao, Zhengwei Li, Yunming Li, Jipeng Zheng, Jianyong Wang, Weizhong Zhao, Qingchuan Ji, Gang Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival |
title | Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival |
title_full | Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival |
title_fullStr | Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival |
title_full_unstemmed | Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival |
title_short | Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival |
title_sort | increased microrna-630 expression in gastric cancer is associated with poor overall survival |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951214/ https://www.ncbi.nlm.nih.gov/pubmed/24621930 http://dx.doi.org/10.1371/journal.pone.0090526 |
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