Biological Evaluation of Isoniazid Derivatives as an Anticancer Class

A series of thirty-two isoniazid derivatives have been evaluated for their activity against four human cancer cell lines with potent cytotoxicity (IC50 ranging from 0.61 to 3.36 μg/mL). The structure-activity relationship (SAR) analysis indicated the number, the positions, and the types of substitue...

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Detalles Bibliográficos
Autores principales: Rodrigues, Felipe A. R., Oliveira, Augusto C. A., Cavalcanti, Bruno C., Pessoa, Claudia, Pinheiro, Alessandra C., de Souza, Marcus V. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951230/
https://www.ncbi.nlm.nih.gov/pubmed/24634839
http://dx.doi.org/10.3797/scipharm.1307-25

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