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Nicotine Activates YAP1 through nAChRs Mediated Signaling in Esophageal Squamous Cell Cancer (ESCC)

Cigarette smoking is an established risk factor for esophageal cancers. Yes-associated protein 1 (YAP1), the key transcription factor of the mammalian Hippo pathway, has been reported to be an oncogenic factor for many cancers. In this study, we find nicotine administration can induce nuclear transl...

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Detalles Bibliográficos
Autores principales: Zhao, Yue, Zhou, Wei, Xue, Liyan, Zhang, Weimin, Zhan, Qimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951250/
https://www.ncbi.nlm.nih.gov/pubmed/24621512
http://dx.doi.org/10.1371/journal.pone.0090836