The Pathophysiologic Roles of TRPM7 Channel

Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg(2+) and Ca(2+), and i...

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Detalles Bibliográficos
Autores principales: Park, Hyun Soo, Hong, Chansik, Kim, Byung Joo, So, Insuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951819/
https://www.ncbi.nlm.nih.gov/pubmed/24634592
http://dx.doi.org/10.4196/kjpp.2014.18.1.15
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author Park, Hyun Soo
Hong, Chansik
Kim, Byung Joo
So, Insuk
author_facet Park, Hyun Soo
Hong, Chansik
Kim, Byung Joo
So, Insuk
author_sort Park, Hyun Soo
collection PubMed
description Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg(2+) and Ca(2+), and its channel activity is negatively regulated by free Mg(2+) and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases.
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spelling pubmed-39518192014-03-14 The Pathophysiologic Roles of TRPM7 Channel Park, Hyun Soo Hong, Chansik Kim, Byung Joo So, Insuk Korean J Physiol Pharmacol Review Article Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg(2+) and Ca(2+), and its channel activity is negatively regulated by free Mg(2+) and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases. The Korean Physiological Society and The Korean Society of Pharmacology 2014-02 2014-02-13 /pmc/articles/PMC3951819/ /pubmed/24634592 http://dx.doi.org/10.4196/kjpp.2014.18.1.15 Text en Copyright © 2014 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Park, Hyun Soo
Hong, Chansik
Kim, Byung Joo
So, Insuk
The Pathophysiologic Roles of TRPM7 Channel
title The Pathophysiologic Roles of TRPM7 Channel
title_full The Pathophysiologic Roles of TRPM7 Channel
title_fullStr The Pathophysiologic Roles of TRPM7 Channel
title_full_unstemmed The Pathophysiologic Roles of TRPM7 Channel
title_short The Pathophysiologic Roles of TRPM7 Channel
title_sort pathophysiologic roles of trpm7 channel
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951819/
https://www.ncbi.nlm.nih.gov/pubmed/24634592
http://dx.doi.org/10.4196/kjpp.2014.18.1.15
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