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Selective deletion of the endothelial sphingosine-1-phosphate 1 receptor exacerbates kidney ischemia-reperfusion injury

The role for the endothelial sphingosine-1-phosphate 1 receptor (S1P1R) in acute kidney injury (AKI) remains unclear as germline endothelial S1P1R deletion is embryonically lethal. Here, we generated conditional endothelial S1P1R deficiency by crossing mice with floxed S1P1R with mice expressing a t...

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Bibliografiska uppgifter
Huvudupphovsmän: Ham, Ahrom, Kim, Mihwa, Kim, Joo Yun, Brown, Kevin M., Fruttiger, Marcus, D’Agati, Vivette D., Lee, H. Thomas
Materialtyp: Online Artikel Text
Språk:English
Publicerad: 2013
Ämnen:
Länkar:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952061/
https://www.ncbi.nlm.nih.gov/pubmed/24025642
http://dx.doi.org/10.1038/ki.2013.345