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Dynamic regulation and function of histone monoubiquitination in plants

Polyubiquitin chain deposition on a target protein frequently leads to proteasome-mediated degradation whereas monoubiquitination modifies target protein property and function independent of proteolysis. Histone monoubiquitination occurs in chromatin and is in nowadays recognized as one critical typ...

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Autores principales: Feng, Jing, Shen, Wen-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952079/
https://www.ncbi.nlm.nih.gov/pubmed/24659991
http://dx.doi.org/10.3389/fpls.2014.00083
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author Feng, Jing
Shen, Wen-Hui
author_facet Feng, Jing
Shen, Wen-Hui
author_sort Feng, Jing
collection PubMed
description Polyubiquitin chain deposition on a target protein frequently leads to proteasome-mediated degradation whereas monoubiquitination modifies target protein property and function independent of proteolysis. Histone monoubiquitination occurs in chromatin and is in nowadays recognized as one critical type of epigenetic marks in eukaryotes. While H2A monoubiquitination (H2Aub1) is generally associated with transcription repression mediated by the Polycomb pathway, H2Bub1 is involved in transcription activation. H2Aub1 and H2Bub1 levels are dynamically regulated via deposition and removal by specific enzymes. We review knows and unknowns of dynamic regulation of H2Aub1 and H2Bub1 deposition and removal in plants and highlight the underlying crucial functions in gene transcription, cell proliferation/differentiation, and plant growth and development. We also discuss crosstalks existing between H2Aub1 or H2Bub1 and different histone methylations for an ample mechanistic understanding.
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spelling pubmed-39520792014-03-21 Dynamic regulation and function of histone monoubiquitination in plants Feng, Jing Shen, Wen-Hui Front Plant Sci Plant Science Polyubiquitin chain deposition on a target protein frequently leads to proteasome-mediated degradation whereas monoubiquitination modifies target protein property and function independent of proteolysis. Histone monoubiquitination occurs in chromatin and is in nowadays recognized as one critical type of epigenetic marks in eukaryotes. While H2A monoubiquitination (H2Aub1) is generally associated with transcription repression mediated by the Polycomb pathway, H2Bub1 is involved in transcription activation. H2Aub1 and H2Bub1 levels are dynamically regulated via deposition and removal by specific enzymes. We review knows and unknowns of dynamic regulation of H2Aub1 and H2Bub1 deposition and removal in plants and highlight the underlying crucial functions in gene transcription, cell proliferation/differentiation, and plant growth and development. We also discuss crosstalks existing between H2Aub1 or H2Bub1 and different histone methylations for an ample mechanistic understanding. Frontiers Media S.A. 2014-03-13 /pmc/articles/PMC3952079/ /pubmed/24659991 http://dx.doi.org/10.3389/fpls.2014.00083 Text en Copyright © 2014 Feng and Shen. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Feng, Jing
Shen, Wen-Hui
Dynamic regulation and function of histone monoubiquitination in plants
title Dynamic regulation and function of histone monoubiquitination in plants
title_full Dynamic regulation and function of histone monoubiquitination in plants
title_fullStr Dynamic regulation and function of histone monoubiquitination in plants
title_full_unstemmed Dynamic regulation and function of histone monoubiquitination in plants
title_short Dynamic regulation and function of histone monoubiquitination in plants
title_sort dynamic regulation and function of histone monoubiquitination in plants
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952079/
https://www.ncbi.nlm.nih.gov/pubmed/24659991
http://dx.doi.org/10.3389/fpls.2014.00083
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