Cargando…
Mutagenicity and Genotoxicity of (5′S)-8,5′-Cyclo-2′-deoxyadenosine in Escherichia coli and Replication of (5′S)-8,5′-Cyclopurine-2′-deoxynucleosides in Vitro by DNA Polymerase IV, Exo-Free Klenow Fragment, and Dpo4
[Image: see text] Reactive oxygen species generate many lesions in DNA, including R and S diastereomers of 8,5′-cyclo-2′-deoxyadenosine (cdA) and 8,5′-cyclo-2′-deoxyguanosine (cdG). Herein, the result of replication of a plasmid containing S-cdA in Escherichia coli is reported. S-cdA was found mutag...
Autores principales: | Pednekar, Varsha, Weerasooriya, Savithri, Jasti, Vijay P., Basu, Ashis K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952113/ https://www.ncbi.nlm.nih.gov/pubmed/24392701 http://dx.doi.org/10.1021/tx4002786 |
Ejemplares similares
-
(5′S)-8,5′-Cyclo-2′-deoxyguanosine Is a Strong Block to Replication, a Potent pol V-Dependent Mutagenic Lesion, and Is Inefficiently Repaired in Escherichia coli
por: Jasti, Vijay P., et al.
Publicado: (2011) -
In this Issue – 8.5
por: Thomas, Paul
Publicado: (2016) -
Evidence for the Involvement of DNA Repair Enzyme NEIL1 in Nucleotide Excision Repair of (5′R)- and (5′S)-8,5′-Cyclo-2′-deoxyadenosines
por: Jaruga, Pawel, et al.
Publicado: (2010) -
When UDG and hAPE1 Meet Cyclopurines. How (5′R) and (5′S) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?
por: Szewczuk, Michał, et al.
Publicado: (2021) -
Structures of (5′S)-8,5′-Cyclo-2′-deoxyguanosine Mismatched
with dA or dT
por: Huang, Hai, et al.
Publicado: (2012)