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A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition

A novel porous polymeric fluorescence probe, MN-ZIF-90, has been designed and synthesized for quantitative hydrogen sulfide (H(2)S) fluorescent detection and highly selective amino acid recognition. This distinct crystalline structure, derived from rational design and malonitrile functionalization,...

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Autores principales: Li, Haiwei, Feng, Xiao, Guo, Yuexin, Chen, Didi, Li, Rui, Ren, Xiaoqian, Jiang, Xin, Dong, Yuping, Wang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952146/
https://www.ncbi.nlm.nih.gov/pubmed/24621614
http://dx.doi.org/10.1038/srep04366
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author Li, Haiwei
Feng, Xiao
Guo, Yuexin
Chen, Didi
Li, Rui
Ren, Xiaoqian
Jiang, Xin
Dong, Yuping
Wang, Bo
author_facet Li, Haiwei
Feng, Xiao
Guo, Yuexin
Chen, Didi
Li, Rui
Ren, Xiaoqian
Jiang, Xin
Dong, Yuping
Wang, Bo
author_sort Li, Haiwei
collection PubMed
description A novel porous polymeric fluorescence probe, MN-ZIF-90, has been designed and synthesized for quantitative hydrogen sulfide (H(2)S) fluorescent detection and highly selective amino acid recognition. This distinct crystalline structure, derived from rational design and malonitrile functionalization, can trigger significant enhancement of its fluorescent intensity when exposed to H(2)S or cysteine molecules. Indeed this new metal-organic framework (MOF) structure shows high selectivity of biothiols over other amino acids and exhibits favorable stability. Moreover, in vitro viability assays on HeLa cells show low cytotoxicity of MN-ZIF-90 and its imaging contrast efficiency is further demonstrated by fluorescence microscopy studies. This facile yet powerful strategy also offers great potential of using open-framework materials (i.e. MOFs) as the novel platform for sensing and other biological applications.
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spelling pubmed-39521462014-03-19 A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition Li, Haiwei Feng, Xiao Guo, Yuexin Chen, Didi Li, Rui Ren, Xiaoqian Jiang, Xin Dong, Yuping Wang, Bo Sci Rep Article A novel porous polymeric fluorescence probe, MN-ZIF-90, has been designed and synthesized for quantitative hydrogen sulfide (H(2)S) fluorescent detection and highly selective amino acid recognition. This distinct crystalline structure, derived from rational design and malonitrile functionalization, can trigger significant enhancement of its fluorescent intensity when exposed to H(2)S or cysteine molecules. Indeed this new metal-organic framework (MOF) structure shows high selectivity of biothiols over other amino acids and exhibits favorable stability. Moreover, in vitro viability assays on HeLa cells show low cytotoxicity of MN-ZIF-90 and its imaging contrast efficiency is further demonstrated by fluorescence microscopy studies. This facile yet powerful strategy also offers great potential of using open-framework materials (i.e. MOFs) as the novel platform for sensing and other biological applications. Nature Publishing Group 2014-03-13 /pmc/articles/PMC3952146/ /pubmed/24621614 http://dx.doi.org/10.1038/srep04366 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Li, Haiwei
Feng, Xiao
Guo, Yuexin
Chen, Didi
Li, Rui
Ren, Xiaoqian
Jiang, Xin
Dong, Yuping
Wang, Bo
A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition
title A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition
title_full A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition
title_fullStr A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition
title_full_unstemmed A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition
title_short A malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition
title_sort malonitrile-functionalized metal-organic framework for hydrogen sulfide detection and selective amino acid molecular recognition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952146/
https://www.ncbi.nlm.nih.gov/pubmed/24621614
http://dx.doi.org/10.1038/srep04366
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