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Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence
Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge–basal ganglia....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952815/ https://www.ncbi.nlm.nih.gov/pubmed/24626189 http://dx.doi.org/10.1371/journal.pcbi.1003495 |
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author | Chen, Mingming Guo, Daqing Wang, Tiebin Jing, Wei Xia, Yang Xu, Peng Luo, Cheng Valdes-Sosa, Pedro A. Yao, Dezhong |
author_facet | Chen, Mingming Guo, Daqing Wang, Tiebin Jing, Wei Xia, Yang Xu, Peng Luo, Cheng Valdes-Sosa, Pedro A. Yao, Dezhong |
author_sort | Chen, Mingming |
collection | PubMed |
description | Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge–basal ganglia. It has been thus postulated that the basal ganglia might play key roles in the modulation of absence seizures, but the relevant biophysical mechanisms are still not completely established. Using a biophysically based model, we demonstrate here that the typical absence seizure activities can be controlled and modulated by the direct GABAergic projections from the substantia nigra pars reticulata (SNr) to either the thalamic reticular nucleus (TRN) or the specific relay nuclei (SRN) of thalamus, through different biophysical mechanisms. Under certain conditions, these two types of seizure control are observed to coexist in the same network. More importantly, due to the competition between the inhibitory SNr-TRN and SNr-SRN pathways, we find that both decreasing and increasing the activation of SNr neurons from the normal level may considerably suppress the generation of spike-and-slow wave discharges in the coexistence region. Overall, these results highlight the bidirectional functional roles of basal ganglia in controlling and modulating absence seizures, and might provide novel insights into the therapeutic treatments of this brain disorder. |
format | Online Article Text |
id | pubmed-3952815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39528152014-03-18 Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence Chen, Mingming Guo, Daqing Wang, Tiebin Jing, Wei Xia, Yang Xu, Peng Luo, Cheng Valdes-Sosa, Pedro A. Yao, Dezhong PLoS Comput Biol Research Article Absence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus also communicate indirectly through an important intermediate bridge–basal ganglia. It has been thus postulated that the basal ganglia might play key roles in the modulation of absence seizures, but the relevant biophysical mechanisms are still not completely established. Using a biophysically based model, we demonstrate here that the typical absence seizure activities can be controlled and modulated by the direct GABAergic projections from the substantia nigra pars reticulata (SNr) to either the thalamic reticular nucleus (TRN) or the specific relay nuclei (SRN) of thalamus, through different biophysical mechanisms. Under certain conditions, these two types of seizure control are observed to coexist in the same network. More importantly, due to the competition between the inhibitory SNr-TRN and SNr-SRN pathways, we find that both decreasing and increasing the activation of SNr neurons from the normal level may considerably suppress the generation of spike-and-slow wave discharges in the coexistence region. Overall, these results highlight the bidirectional functional roles of basal ganglia in controlling and modulating absence seizures, and might provide novel insights into the therapeutic treatments of this brain disorder. Public Library of Science 2014-03-13 /pmc/articles/PMC3952815/ /pubmed/24626189 http://dx.doi.org/10.1371/journal.pcbi.1003495 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chen, Mingming Guo, Daqing Wang, Tiebin Jing, Wei Xia, Yang Xu, Peng Luo, Cheng Valdes-Sosa, Pedro A. Yao, Dezhong Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence |
title | Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence |
title_full | Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence |
title_fullStr | Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence |
title_full_unstemmed | Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence |
title_short | Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence |
title_sort | bidirectional control of absence seizures by the basal ganglia: a computational evidence |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952815/ https://www.ncbi.nlm.nih.gov/pubmed/24626189 http://dx.doi.org/10.1371/journal.pcbi.1003495 |
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